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- W1984829970 endingPage "1058" @default.
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- W1984829970 abstract "Introduction Recipient mouse selection for engrafting xenogeneic human haematopoietic and immune cells Pre‐conditioning regimens for establishing humanized mice Transplantation strategies to establish humanized mice A proposed ideal humanized mouse model Applications of humanized mouse models in biomedical research Conclusions and perspectives Abstract Biomedical research in human beings is largely restricted to in vitro studies that lack complexity of a living organism. To overcome this limitation, humanized mouse models are developed based on immunodeficient characteristics of severe combined immunodeficiency (SCID) or recombination activating gene (Rag) null mice, which can accept xenografts. Peripheral constitution of human immunity in SCID or Rag null mice has been achieved by transplantation of mature human immune cells, foetal human thymus, bone marrow, liver tissues, lymph nodes or a combination of these, although efficiency needs to be improved. These mouse models with constituted human immunity (defined as humanized mice in the present text) have been widely used to investigate the basic principles of human immunobiology as well as complex pathomechanisms and potential therapies of human diseases. Here, elements of an ideal humanized mouse model are highlighted including genetic and non‐genetic modification of recipient mice, transplantation strategies and proposals to improve engraftments. The applications of the humanized mice to study the development and response of human immune cells, human autoimmune diseases, virus infections, transplantation biology and tumour biology are reviewed as well." @default.
- W1984829970 created "2016-06-24" @default.
- W1984829970 creator A5014246118 @default.
- W1984829970 creator A5042840845 @default.
- W1984829970 creator A5085383685 @default.
- W1984829970 date "2009-06-01" @default.
- W1984829970 modified "2023-10-12" @default.
- W1984829970 title "Mouse models with human immunity and their application in biomedical research" @default.
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