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- W1984832101 abstract "Developing novel combined-modality therapeutic approaches based on understanding of the involvement of redox biology in apoptosis of malignant cells is a promising approach for improving clinical responses in B-cell lymphoma and multiple myeloma. Therapeutic modalities that generate reactive oxygen species (i.e., radiation, photodynamic therapy, and specific chemotherapeutic drugs) have been shown to be selectively cytotoxic to malignant B-cells. In this review, we will discuss agents that induce apoptosis in B-cell tumors by oxidative stress. Subsequently, a novel biochemical rationale (based on fundamental differences in cancer vs. normal cell oxidative metabolism) for combining oxidative stressors with radiotherapy and chemotherapy, that may lead to designing of more effective treatment strategies for B-cell malignancies, will be discussed. Besides providing potential curative benefit, such novel therapies could also selectively target and inhibit the emergence of drug-resistance in tumor cells, which is a major determinant of treatment failure in many B-cell malignancies." @default.
- W1984832101 created "2016-06-24" @default.
- W1984832101 creator A5001607309 @default.
- W1984832101 creator A5002846184 @default.
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- W1984832101 date "2012-01-05" @default.
- W1984832101 modified "2023-10-01" @default.
- W1984832101 title "Manipulation of cellular redox parameters for improving therapeutic responses in B-cell lymphoma and multiple myeloma" @default.
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- W1984832101 doi "https://doi.org/10.1002/jcb.23387" @default.
- W1984832101 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3374635" @default.
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