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- W1984838615 abstract "Gliomas constitute a heterogeneous group of neoplasms with variation in growth potential and progression, in morphological features, in extent of invasiveness and in response to treatment. Specific molecular alterations are associated with astrocytic gliomas, which are responsible for the differences in their biological behaviour. In our present study, epidermal growth factor receptor (EGFR) gene is over expressed in high grade gliomas which is known to play a role in the malignant progression of these neoplasms. EGFR expression and amplification in different grades of gliomas were examined using immuno histochemistry and PCR technique respectively. This was further correlated with Tenascin C, a molecule associated with invasiveness and angiogenetic nature of astrocytic gliomas. The elevation of tenascin C expression strongly reflects the aggressive nature of the tumour. These studies demonstrate that upregulation of gene expression is related to invasive phenotype of high grade gliomas. doi: 10.5214/ans.0972.7531.2005.120403" @default.
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- W1984838615 date "2005-10-01" @default.
- W1984838615 modified "2023-09-26" @default.
- W1984838615 title "Epidermal Growth Eactor Receptor and Tenascin Expression in Astrocytic Gliomas" @default.
- W1984838615 doi "https://doi.org/10.5214/126" @default.
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