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• W1984849905 abstract "Effects of NG-nitro-l-arginine methyl ester (l-NAME; an inhibitor of nitric oxide (NO) synthase) and/or l-arginine (substrate of NO synthase) on pulmonary metastasis of murine melanoma and Lewis lung carcinoma cells were investigated. l-NAME, l-arginine, or both l-NAME and l-arginine was injected i.p. into mice 5, 3, and 1 h before and 1, 3, 5, and 7 h after the injection of tumor cells into mice via a tail vein. The administration of l-NAME (9.3 μmol/mouse) alone or l-arginine alone (46.5 or 186 μmol/mouse) potentiated pulmonary metastasis of highly and poorly metastatic B16 melanoma cells. l-NAME alone also increased the number of pulmonary metastasis of Lewis lung carcinoma cells, but l-arginine (185 μmol/mouse) did not. However, the combination of l-NAME and l-arginine increased the number of pulmonary metastasis of both the melanoma and Lewis lung carcinoma cells synergistically. l-NAME or l-arginine administration enhanced the retention of B16 melanoma cells in the lungs examined 24 h after the tumor cell injection. Synergistic effect of l-NAME and l-arginine was also seen in the tumor cell retention. The present results suggest that the metastatic potentials of the tumor cells do not simply correlate to NO production in vivo." @default.
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• W1984849905 date "1994-11-01" @default.
• W1984849905 modified "2023-09-26" @default.
• W1984849905 title "Effects of NG-nitro-l-arginine and/or l-arginine on experimental pulmonary metastasis in mice" @default.
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• W1984849905 doi "https://doi.org/10.1016/0304-3835(94)90417-0" @default.
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