FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984882006> ?p ?o ?g. }

• W1984882006 endingPage "e64827" @default.
• W1984882006 startingPage "e64827" @default.
• W1984882006 abstract "Purpose Carbamazepine (CBZ) is used as the first line of treatment of Complex Partial Seizures (CPS) in the Epilepsy Clinic, Neurology Department of Kuala Lumpur Hospital (KLH). More than 30% of the patients remain drug resistant to CBZ mono-therapy. CBZ is transported by the P-glycoprotein (P-gp). The P-gp encoded by the ABCB1 and ABCC2 genes are expressed in drug resistant patients with epilepsy. A few studies have shown significant association between CBZ resistant epilepsy and Linkage Disequilibrium (LD) with adjacent polymorphisms of these genes. Our study is aimed at determining the correlation between patients' response to CBZ mono-therapy to Single Nucleotide Polymorphisms G2677T and C3435T of the ABCB1 gene as well as G1249A and −24C>T of the ABCC2 gene. Method 314 patients with CPS were recruited from the Neurology Department of the KLH based on stringent inclusion and exclusion criteria, of whom 152 were responders and the other 162 were non-responders. DNA was extracted from their blood samples and Taqman technology for allelic discrimination was performed. Results were described as genotype frequencies. The SHEsis analysis platform was used to calculate linkage disequilibrium index and infer haplotype frequencies. Haploview was used to do permutation test to obtain a corrected p-value. Results Resistance to treatment with CBZ mono-therapy was significantly associated with the 2677TT and the 3435TT genotypes while it was not significantly associated with the G1249A and −24C>T polymorphisms. The GCGC haplotype combination of the 2677G>T, 3435C>T, 1249G>A and −24C>T respectively was found to be extremely significant (p = 1.10e−20) with good drug response to CBZ mono-therapy. Conclusion Linkage disequilibrium between the 2677G>T, 3435C>T, 1249G>A and −24C>T SNPs may be used as a reliable screening marker to determine the treatment outcome of CBZ mono-therapy with CPS irrespective of race or gender." @default.
• W1984882006 created "2016-06-24" @default.
• W1984882006 creator A5008172133 @default.
• W1984882006 creator A5011513263 @default.
• W1984882006 creator A5036284999 @default.
• W1984882006 creator A5045858659 @default.
• W1984882006 creator A5067782910 @default.
• W1984882006 creator A5070124485 @default.
• W1984882006 creator A5083065198 @default.
• W1984882006 creator A5086121320 @default.
• W1984882006 date "2013-05-23" @default.
• W1984882006 modified "2023-10-03" @default.
• W1984882006 title "Linkage Disequilibrium between Polymorphisms of ABCB1 and ABCC2 to Predict the Treatment Outcome of Malaysians with Complex Partial Seizures on Treatment with Carbamazepine Mono-Therapy at the Kuala Lumpur Hospital" @default.
• W1984882006 cites W1505376713 @default.
• W1984882006 cites W1958692533 @default.
• W1984882006 cites W1966598665 @default.
• W1984882006 cites W1998742400 @default.
• W1984882006 cites W2013047801 @default.
• W1984882006 cites W2013533336 @default.
• W1984882006 cites W2022880217 @default.
• W1984882006 cites W2030447006 @default.
• W1984882006 cites W2030449842 @default.
• W1984882006 cites W2031178488 @default.
• W1984882006 cites W2032417894 @default.
• W1984882006 cites W2054216255 @default.
• W1984882006 cites W2054458932 @default.
• W1984882006 cites W2061230148 @default.
• W1984882006 cites W2066631565 @default.
• W1984882006 cites W2070781819 @default.
• W1984882006 cites W2092933004 @default.
• W1984882006 cites W2101382252 @default.
• W1984882006 cites W2107373964 @default.
• W1984882006 cites W2110526135 @default.
• W1984882006 cites W2124714417 @default.
• W1984882006 cites W2125142522 @default.
• W1984882006 cites W2148776940 @default.
• W1984882006 cites W2153605537 @default.
• W1984882006 cites W25713858 @default.
• W1984882006 cites W4236676256 @default.
• W1984882006 doi "https://doi.org/10.1371/journal.pone.0064827" @default.
• W1984882006 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3662793" @default.
• W1984882006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23717663" @default.
• W1984882006 hasPublicationYear "2013" @default.
• W1984882006 type Work @default.
• W1984882006 sameAs 1984882006 @default.
• W1984882006 citedByCount "31" @default.
• W1984882006 countsByYear W19848820062014 @default.
• W1984882006 countsByYear W19848820062015 @default.
• W1984882006 countsByYear W19848820062016 @default.
• W1984882006 countsByYear W19848820062017 @default.
• W1984882006 countsByYear W19848820062019 @default.
• W1984882006 countsByYear W19848820062020 @default.
• W1984882006 countsByYear W19848820062021 @default.
• W1984882006 countsByYear W19848820062022 @default.
• W1984882006 countsByYear W19848820062023 @default.
• W1984882006 crossrefType "journal-article" @default.
• W1984882006 hasAuthorship W1984882006A5008172133 @default.
• W1984882006 hasAuthorship W1984882006A5011513263 @default.
• W1984882006 hasAuthorship W1984882006A5036284999 @default.
• W1984882006 hasAuthorship W1984882006A5045858659 @default.
• W1984882006 hasAuthorship W1984882006A5067782910 @default.
• W1984882006 hasAuthorship W1984882006A5070124485 @default.
• W1984882006 hasAuthorship W1984882006A5083065198 @default.
• W1984882006 hasAuthorship W1984882006A5086121320 @default.
• W1984882006 hasBestOaLocation W19848820061 @default.
• W1984882006 hasConcept C104317684 @default.
• W1984882006 hasConcept C118552586 @default.
• W1984882006 hasConcept C126322002 @default.
• W1984882006 hasConcept C135763542 @default.
• W1984882006 hasConcept C143998085 @default.
• W1984882006 hasConcept C153209595 @default.
• W1984882006 hasConcept C197754878 @default.
• W1984882006 hasConcept C2778186239 @default.
• W1984882006 hasConcept C2779253243 @default.
• W1984882006 hasConcept C35605836 @default.
• W1984882006 hasConcept C54355233 @default.
• W1984882006 hasConcept C71924100 @default.
• W1984882006 hasConcept C86803240 @default.
• W1984882006 hasConcept C90924648 @default.
• W1984882006 hasConcept C98274493 @default.
• W1984882006 hasConceptScore W1984882006C104317684 @default.
• W1984882006 hasConceptScore W1984882006C118552586 @default.
• W1984882006 hasConceptScore W1984882006C126322002 @default.
• W1984882006 hasConceptScore W1984882006C135763542 @default.
• W1984882006 hasConceptScore W1984882006C143998085 @default.
• W1984882006 hasConceptScore W1984882006C153209595 @default.
• W1984882006 hasConceptScore W1984882006C197754878 @default.
• W1984882006 hasConceptScore W1984882006C2778186239 @default.
• W1984882006 hasConceptScore W1984882006C2779253243 @default.
• W1984882006 hasConceptScore W1984882006C35605836 @default.
• W1984882006 hasConceptScore W1984882006C54355233 @default.
• W1984882006 hasConceptScore W1984882006C71924100 @default.
• W1984882006 hasConceptScore W1984882006C86803240 @default.
• W1984882006 hasConceptScore W1984882006C90924648 @default.
• W1984882006 hasConceptScore W1984882006C98274493 @default.
• W1984882006 hasIssue "5" @default.
• W1984882006 hasLocation W19848820061 @default.
• W1984882006 hasLocation W19848820062 @default.

• next