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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984882015> ?p ?o ?g. }

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• W1984882015 abstract "Certain derivatives of p-phenylenediamine have been shown to cause necrosis of cardiac and skeletal muscle in rats; in vitro, such compounds are known to autoxidize to the corresponding radical cations, with concomitant formation of oxygen free-radicals. In the present study, the autoxidation rates of p-phenylenediamine and its N-methyl, dimethyl, trimethyl and tetramethyl derivatives have been determined and compared with the severity of the muscle necrosis induced by each of these compounds in rats. A close correlation was observed between autoxidation rate in vitro and toxicity in vivo, suggesting that free-radical species may be involved in the initiation of the muscle damage caused by these substances." @default.
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• W1984882015 date "1989-08-01" @default.
• W1984882015 modified "2023-09-26" @default.
• W1984882015 title "Muscle necrosis by N-methylated p-phenylenediamines in rats: Structure-activity relationships and correlation with free-radical production in vitro" @default.
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• W1984882015 doi "https://doi.org/10.1016/0300-483x(89)90118-2" @default.
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