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• W1984889622 abstract "The impact of troposphere ozone (O3), the major oxidant in photochemical smog, on the overall wellbeing of skin is of considerable interest. To date, limited information is available on the impact of O3 on human skin. Using a specially designed O3 exposure chamber, we provide the first evidence that exposure of human skin to O3 (0.8 ppm, 2-h time-weighted average) significantly reduced vitamin E by 70% and concomitantly increased lipid hydroperoxides by 2.3 fold in the superficial stratum corneum (SC). Although the dose of O3 used here reduced the resident microflora population by 50% and created a state of oxidative stress within the SC, it did not affect several key enzymes involved in SC homeostasis including the redox-sensitive transglutaminase and the SC tryptic (KLK5) and chymotryptic (KLK7) proteases. Importantly, no signs of skin dryness or erythema were observed. We hypothesize that the limited effects of low doses of O3 on SC function is attributable to several factors including: (i) protection provided by the anti-oxidant defence system; (ii) inability of O3 to penetrate the SC; and (iii) limited water available to catalyse the Criegee reaction. Although chronic exposure to O3 may produce a different outcome than that reported here, our data suggest that exposure to environmentally relevant doses of O3, at best, induces a moderate state of oxidative stress, without producing a visible clinical response. In our opinion, exposure of skin to UV radiation is a much more significant threat than exposure to ground-level O3. L'impact de l'ozone troposphérique (03), le principal oxydant du smog photochimque, sur le confort global de la peau est d'un intérêt considérable. Jusqu’à présent, il n'y a que des informations limitées sur l'impact de l'ozone sur la peau humaine. En utilisant une chambre d'exposition à l'ozone spécialement adaptée, nous fournissons la première preuve que l'exposition de la peau humaine à l'ozone (0,8 ppm, 2 heures) diminue significativement la vitamine E de 70% tout en augmentant de 2,3 fois les hydroperoxydes lipidiques dans le stratum corneum superficel. Bien que la dose d'ozone utilisée réduise la population de la microflore résidente de 50% et crée un état de stress oxydatif dans le stratum corneum, elle n'affecte pas plusieurs enzymes clés impliquées dans l'homéostasie du stratum corneum comme la transglutaminase redox-sensitive et les protéases tryptiques (KLK5) et chymotryptiques (KLK7). Soulignons qu'aucun signe de sécheresse cutanée ou d’érythème n'a été observé. Supposons que les effets limités de faibles doses d'ozone sur les formations du stratum corneum sont dus à plusieurs facteurs parmi lesquels: 1/ la protection produite par le système de défense antioxydant 2/ l'incapacité de l'ozone à traverser le stratum corneum et 3/ la quantité limitée d'eau capable de catalyser la réaction de Grieggee. Bien qu'une exposition chronique à l'ozone puisse produire des effets différents de ceux rapportés ici, nos résultats suggèrent qu'une exposition aux doses d'ozone environnementales, au mieux induit un état modéré de stress oxydatif, sans provoquer de réponse clinique visible. A notre opinion, l'exposition de la peau aux radiations UV est une bien plus grande menace qu'une exposition à l'ozone au niveau du sol." @default.
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• W1984889622 date "2006-10-01" @default.
• W1984889622 modified "2023-09-24" @default.
• W1984889622 title "Effects of environmentally realistic levels of ozone on stratum corneum function" @default.
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• W1984889622 doi "https://doi.org/10.1111/j.1467-2494.2006.00347.x" @default.
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