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• W1984899764 abstract "To investigate expression of microRNA (miRNA) and potential targets in chemotherapy resistant esophageal cancer cell lines.An in-vitro model of acquired chemotherapy resistance in esophageal adeno- (EAC) and squamous cell carcinoma (ESCC) cells was used, and microRNA expression profiles for cisplatin or 5-fluorouracil (5-FU) resistant variants vs chemotherapy sensitive controls were compared using microarray and quantitative real-time polymerase chain reaction (PCR). The expression of chemotherapy-relevant genes potentially targeted by the dysregulated microRNAs in the chemotherapy resistant variants was also evaluated.Chemotherapy resistant sublines were found to have specific miRNA signatures, and these miRNA signatures were different for the cisplatin vs 5-FU resistant cells from the same tumor cell line, and also for EAC vs ESCC cells with resistance to the same specific chemotherapy agent. Amongst others, miR-27b-3p, miR-193b-3p, miR-192-5p, miR-378 a-3p, miR-125a-5p and miR-18a-3p were dysregulated, consistent with negative posttranscriptional control of KRAS, TYMS, ABCC3, CBL-B and ERBB2 expression via these miRNAs.The current study supports the hypothesis that microRNA expression has an impact on chemotherapy resistance in esophageal cancer." @default.
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• W1984899764 date "2014-01-01" @default.
• W1984899764 modified "2023-09-26" @default.
• W1984899764 title "MicroRNA signatures in chemotherapy resistant esophageal cancer cell lines" @default.
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• W1984899764 doi "https://doi.org/10.3748/wjg.v20.i40.14904" @default.
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