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- W1984911716 abstract "The aim of the present investigation was to study the possible synergistic effect between cyclosporin A (CsA) and antithymocyte globulin (ATG), using the potent immunostimulator, Linomide®. DA rats were transplanted with a PVG/c heart to the neck vessels, and the recipients were treated for 10 days with oral CsA (10 mg/kg), oral Linomide® (160 mg/kg) and/or ATG, which was given as a single dose of either 0.02 ml, 0.1 ml or 0.2 ml prior to transplantation. Rats given a combination of ATG and Linomide® or CsA and Linomide® were used as controls. Synergism between CsA and ATG was tested using the two immunosuppressive drugs given in combination in order to override the challenge of Linomide®. CsA or ATG treatment alone resulted in rats with long-term surviving grafts. Addition of Linomide® to CsA-treated recipients was followed by early graft rejection. Similarily, Linomide® triggered rejection in rats given a low dose of ATG and in recipients given a high dose of ATG if Linomide® treatment was prolonged to 21 days. The combination of ATG, CsA and 21 days of Linomide® resulted in a significantly prolonged graft survival compared with either ATG + Linomide® or CsA + Linomide®. These findings demonstrate the synergistic capacity of ATG and CsA in combined immunosuppressive therapy." @default.
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- W1984911716 date "1999-01-01" @default.
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- W1984911716 title "Antithymocyte Globulin and Cyclosporin A are Synergistic in an Experimental Transplantation Tolerance Model in the Rat" @default.
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- W1984911716 doi "https://doi.org/10.1046/j.1365-3083.1999.00453.x" @default.
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