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• W1984912627 abstract "Dysregulated tonic pupil size has been reported in autism spectrum disorder (ASD). Among the possible sources of this dysregulation are disruptions in the feedback loop between norepinephrine (NE) and hypothalamic systems. In the current study, we examined afternoon levels of salivary alpha-amylase (sAA, a putative correlate of NE) and cortisol (used to assess stress-based responses) in two independent samples of children with ASD. We found a larger pupil size and lower sAA levels in ASD, compared to typical and clinical age-matched controls. This was substantiated at the individual level, as sAA levels were strongly correlated with tonic pupil size. Relatively little diurnal variation in sAA taken in the home environment in the ASD group was also observed, while typical controls showed a significant linear increase throughout the day. Results are discussed in terms of potential early biomarkers and the elucidation of underlying neural dysfunction in ASD. © 2012 Wiley Periodicals, Inc. Dev Psychobiol 55: 465–482, 2013" @default.
• W1984912627 created "2016-06-24" @default.
• W1984912627 creator A5012757101 @default.
• W1984912627 creator A5019975616 @default.
• W1984912627 creator A5075119009 @default.
• W1984912627 date "2012-05-29" @default.
• W1984912627 modified "2023-10-10" @default.
• W1984912627 title "Pupil and salivary indicators of autonomic dysfunction in autism spectrum disorder" @default.
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• W1984912627 doi "https://doi.org/10.1002/dev.21051" @default.
• W1984912627 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3832142" @default.
• W1984912627 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22644965" @default.
• W1984912627 hasPublicationYear "2012" @default.
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