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- W1984920581 abstract "Alterations in the thymus were investigated in the early course of SIV infection of rhesus monkeys and compared with age-related and acute accidental thymus atrophy. The SIV-induced pathology was characterized by shrinkage of the thymic parenchyma and capsule, whereas in age-related thymus atrophy, the size of the capsule remained unaltered and the emerging space was filled by fatty tissue. Acute accidental thymus involution is characterized by massive cell death of the thymocytes, but there was no increase in pycnotic thymocytes either in SIV-induced or in age-related thymus atrophy. Ultrastructural analysis revealed no major differences between the juvenile control and the aged thymus. In contrast, SIV-induced thymus atrophy exhibited severe alterations of the epithelial cells of the cortex and the interdigitating dendritic cells, which were not found in the aged thymus nor in the juvnile control cortex. Les altérations du thymus ont été étudiées au cours de l'infection par le SIV (ou VIS, virus de l'immunodéficience simienne) de singes rhésus et comparées avec celles de l'atrophie thymique liée à l'âge et de l'atrophie aiguë accidentelle. La pathologie induite par le SIV est caractérisée par un rétrécissement du parenchyme thymique et de la capsule, alors que dans l'atrophie liée à l'âge la taille de la capsule reste intacte et les vacuités sont envahies par du tissu adipeux. L'involution thymique aiguë accidentelle est caractérisée par une mort cellulaire massive des thymocytes, mais il n'y a pas d'augmentation des thymocytes pycnotiques dans l'atrophie induite par le SIV ou liée à l'âge. L'analyse ultrastructurelle ne révèle pas l'existence de différences majeures entre les thymus témoins jeunes et les thymus âgés. Par contre, dans l'atrophie thymique induite par le SIV on observe des altérations sévères des cellules épithéliales du cortex et des cellules dendritiques interdigitales qu'on ne trouve ni dans les thymus âgés, ni dans le cortex des thymus jeunes témoins." @default.
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- W1984920581 date "1993-01-01" @default.
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- W1984920581 title "The thymic epithelial reticulum and interdigitating cells in SIV-induced thymus atrophy and its comparison with other forms of thymus involution" @default.
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- W1984920581 doi "https://doi.org/10.1016/s0923-2516(06)80017-8" @default.
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