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• W1984927643 abstract "Background: The Dermatology Life Quality Index (DLQI) is a widely used and validated measure of patient-reported outcomes in psoriasis. It has been suggested that unlike the PASI score, where each area of the body is weighted proportionally to the surface area covered, the DLQI is more heavily influenced by areas of the body that are readily visible (head and lower extremities). Therefore, the DLQI may provide information regarding outcomes beyond that described by the PASI score. Objective: To determine whether the DLQI and the PASI are highly related and whether they are affected equally by the same factors. Methods: Two recent double-blind, multi-center clinical trials of etanercept therapy for patients with stable, moderate to severe psoriasis were conducted. In addition to the primary endpoint, the PASI score, patient-reported outcomes were assessed using the DLQI. The DLQI is a self-administered questionnaire consisting of 10 questions measuring 6 subscales: symptoms and feelings, daily activities, leisure, work and school, personal relationships, and treatment. Analyses included all patients, regardless of treatment, who provided data at both baseline and the 12-week assessment (n = 1143). Results: While the correlation between the percent change in the PASI and that for the DLQI was reasonably high (0.613), it was well below a level that would imply redundancy. Similar results were seen for the six scales of the DLQI, as correlations ranged from 0.302 to 0.611. 33% of patients who failed to achieve PASI 50 had at least a 50% improvement in DLQI, while 15% of PASI 50 responders had less than a 50% DLQI improvement. PASI response status does not provide perfect information regarding DLQI response status. Finally, in a regression analysis of the change in the DLQI on the change in the PASI components, the head and lower extremities have a greater weight on DLQI scores (and the trunk and lower extremities have lower weights), compared to those seen for the PASI. For the DLQI the head had a relative weight of 20% (versus 10% for the PASI), the lower extremities 46% (versus 40%), the upper extremities 13% (versus 20%), and the trunk 21% (versus 30%). Furthermore, while these components define the PASI, they only account for 0.271 of the variability in the DLQI. Conclusions: The DLQI and the PASI measure different aspects of psoriasis. The informative value of clinical research in psoriasis is improved by the inclusion of the DLQI." @default.
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• W1984927643 date "2004-03-01" @default.
• W1984927643 modified "2023-10-18" @default.
• W1984927643 title "The dermatology life quality index (DLQI) provides qualitatively different information from the pasi" @default.
• W1984927643 doi "https://doi.org/10.1016/j.jaad.2003.10.547" @default.
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