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- W1984928181 abstract "S100B, a glia-derived calcium binding protein, exhibits strong neurite extension activity in cultured serotonergic neurons. Using S100B-knockout mice, we examined whether this protein possesses in vivo serotonergic trophic activity. The distribution of serotonergic fibers, determined by immunohistochemistry, in the brains of S100B-knockout mice was quite similar to that of wild-type mice. Furthermore, the content of serotonin and its metabolite 5-hydroxyindole-3-acetic acid in knockout mice was also indistinguishable from those of wild-type mice. Our findings argue against the hypothesis that S100B has a crucial role in neurite extension of serotonergic neurons." @default.
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- W1984928181 date "2002-03-01" @default.
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- W1984928181 title "Normal development of serotonergic neurons in mice lacking S100B" @default.
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- W1984928181 doi "https://doi.org/10.1016/s0304-3940(01)02549-6" @default.
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