FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984928802> ?p ?o ?g. }

• W1984928802 endingPage "184" @default.
• W1984928802 startingPage "175" @default.
• W1984928802 abstract "Abstract N ‐arachidonoyl‐dopamine (NADA) is an endogenous ligand at TRPV1 and CB 1 receptors, which are expressed on primary afferent nociceptors. The aim of this study was to determine contributions of proposed pronociceptive TRPV1 and antinociceptive CB 1 receptors to effects of peripheral NADA on primary afferent fibre function. Effects of NADA on primary afferent nociceptor function, determined by whole cell patch clamp and calcium imaging studies of adult dorsal root ganglion (DRG) neurons, were determined. Application of NADA (1 µ m ) to DRG neurons depolarized the resting membrane potential (Vm) from −58 ± 1 to −44 ± 3 mV ( P < 0.00001) and evoked a significant increase ( P < 0.0001) in intracellular calcium (74 ± 11% of response to 60 m m KCl), compared to basal. The TRPV1 receptor antagonist capsazepine abolished NADA‐evoked depolarization of Vm ( P < 0.0001) and NADA‐evoked calcium responses ( P < 0.001), which were also blocked by the CB 1 receptor antagonist SR141716A ( P < 0.001). Effects of NADA (1.5 µg and 5 µg/50 µL) on mechanically evoked responses of dorsal horn neurons in anaesthetized Sprague–Dawley rats were studied. Intraplantar injection of the higher dose of NADA (5 µg/50 µL) studied significantly inhibited innocuous (8, 10 g) mechanically evoked responses of dorsal horn neurons compared to vehicle, effects blocked by intraplantar injection of SR141716A. Higher weight (26–100 g) noxious‐evoked responses of dorsal horn neurons were also significantly inhibited by NADA (5 µg/50 µL), effects blocked by intraplantar injection of the TRPV1 antagonist, iodo‐resiniferatoxin. NADA has a complex pattern of effects on DRG neurons and primary afferent fibres, which is likely to reflect its dual site of action at TRPV1 and CB 1 receptors and the differential expression of these receptors by primary afferent fibres." @default.
• W1984928802 created "2016-06-24" @default.
• W1984928802 creator A5021322976 @default.
• W1984928802 creator A5024563142 @default.
• W1984928802 creator A5040719359 @default.
• W1984928802 creator A5053167046 @default.
• W1984928802 creator A5062657946 @default.
• W1984928802 creator A5087403435 @default.
• W1984928802 date "2004-06-21" @default.
• W1984928802 modified "2023-10-15" @default.
• W1984928802 title "TRPV1 and CB1 receptor-mediated effects of the endovanilloid/endocannabinoid N-arachidonoyl-dopamine on primary afferent fibre and spinal cord neuronal responses in the rat" @default.
• W1984928802 cites W1748514544 @default.
• W1984928802 cites W1817439804 @default.
• W1984928802 cites W1952328179 @default.
• W1984928802 cites W1956978115 @default.
• W1984928802 cites W1967558194 @default.
• W1984928802 cites W1978828934 @default.
• W1984928802 cites W1986861943 @default.
• W1984928802 cites W1989073099 @default.
• W1984928802 cites W1994223329 @default.
• W1984928802 cites W1997800158 @default.
• W1984928802 cites W1997940254 @default.
• W1984928802 cites W2005295755 @default.
• W1984928802 cites W2009483745 @default.
• W1984928802 cites W2009968727 @default.
• W1984928802 cites W2020588358 @default.
• W1984928802 cites W2023486326 @default.
• W1984928802 cites W2024083629 @default.
• W1984928802 cites W2025755800 @default.
• W1984928802 cites W2027484549 @default.
• W1984928802 cites W2028253575 @default.
• W1984928802 cites W2032227292 @default.
• W1984928802 cites W2043677647 @default.
• W1984928802 cites W2049100687 @default.
• W1984928802 cites W2057468498 @default.
• W1984928802 cites W2057891016 @default.
• W1984928802 cites W2058816780 @default.
• W1984928802 cites W2059977407 @default.
• W1984928802 cites W2065249636 @default.
• W1984928802 cites W2066559312 @default.
• W1984928802 cites W2072730289 @default.
• W1984928802 cites W2078910349 @default.
• W1984928802 cites W2083155364 @default.
• W1984928802 cites W2083350393 @default.
• W1984928802 cites W2085802434 @default.
• W1984928802 cites W2085989406 @default.
• W1984928802 cites W2089478925 @default.
• W1984928802 cites W2092897826 @default.
• W1984928802 cites W2106201634 @default.
• W1984928802 cites W2109293109 @default.
• W1984928802 cites W2115760259 @default.
• W1984928802 cites W2128604157 @default.
• W1984928802 cites W2147082948 @default.
• W1984928802 cites W2147672258 @default.
• W1984928802 cites W2159933935 @default.
• W1984928802 cites W2161954110 @default.
• W1984928802 cites W2163841453 @default.
• W1984928802 cites W2172201406 @default.
• W1984928802 doi "https://doi.org/10.1111/j.1460-9568.2004.03481.x" @default.
• W1984928802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15245490" @default.
• W1984928802 hasPublicationYear "2004" @default.
• W1984928802 type Work @default.
• W1984928802 sameAs 1984928802 @default.
• W1984928802 citedByCount "64" @default.
• W1984928802 countsByYear W19849288022012 @default.
• W1984928802 countsByYear W19849288022013 @default.
• W1984928802 countsByYear W19849288022014 @default.
• W1984928802 countsByYear W19849288022015 @default.
• W1984928802 countsByYear W19849288022016 @default.
• W1984928802 countsByYear W19849288022017 @default.
• W1984928802 countsByYear W19849288022018 @default.
• W1984928802 countsByYear W19849288022020 @default.
• W1984928802 countsByYear W19849288022021 @default.
• W1984928802 countsByYear W19849288022022 @default.
• W1984928802 crossrefType "journal-article" @default.
• W1984928802 hasAuthorship W1984928802A5021322976 @default.
• W1984928802 hasAuthorship W1984928802A5024563142 @default.
• W1984928802 hasAuthorship W1984928802A5040719359 @default.
• W1984928802 hasAuthorship W1984928802A5053167046 @default.
• W1984928802 hasAuthorship W1984928802A5062657946 @default.
• W1984928802 hasAuthorship W1984928802A5087403435 @default.
• W1984928802 hasConcept C126322002 @default.
• W1984928802 hasConcept C134018914 @default.
• W1984928802 hasConcept C15490471 @default.
• W1984928802 hasConcept C155164980 @default.
• W1984928802 hasConcept C160145004 @default.
• W1984928802 hasConcept C169760540 @default.
• W1984928802 hasConcept C170493617 @default.
• W1984928802 hasConcept C172659308 @default.
• W1984928802 hasConcept C185592680 @default.
• W1984928802 hasConcept C2776281502 @default.
• W1984928802 hasConcept C2780071552 @default.
• W1984928802 hasConcept C2780775167 @default.
• W1984928802 hasConcept C519063684 @default.
• W1984928802 hasConcept C71924100 @default.
• W1984928802 hasConcept C86803240 @default.
• W1984928802 hasConcept C93872552 @default.
• W1984928802 hasConcept C98274493 @default.

• next