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• W1984938201 abstract "<i>Objective:</i> We evaluated whether immunoblotting is capable of substantiating the posttreatment clinical assessment of patients with erythema migrans (EM), the hallmark of early Lyme borreliosis. <i>Methods:</i> In 50 patients, seroreactivity to different antigens of <i>Borrelia burgdorferi</i> sensu lato was analyzed by a recombinant immunoblot test (IB) in consecutive serum samples from a minimum follow-up period of 1 year. Antigens in the IgG test were decorin-binding protein A, internal fragment of p41 (p41i), outer surface protein C (OspC), p39, variable major protein-like sequence expressed (VlsE), p58 and p100; those in the IgM test were p41i, OspC and p39. Immune responses were correlated with clinical and treatment-related parameters. <i>Results:</i> Positive IB results were found in 50% before, in 57% directly after therapy and in 44% by the end of the follow-up for the IgG class, and in 36, 43 and 12% for the IgM class. In acute and convalescence phase sera, VlsE was most immunogenic on IgG testing (60 and 70%), and p41i (46 and 57%) and OspC (40 and 57%) for the IgM class. By the end of the follow-up, only the anti-p41i IgM response was significantly decreased to 24%. <i>Conclusions:</i> No correlation was found between IB results and treatment-related parameters. Thus, immunoblotting does not add to the clinical assessment of EM patients after treatment." @default.
• W1984938201 created "2016-06-24" @default.
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• W1984938201 date "2008-01-01" @default.
• W1984938201 modified "2023-10-16" @default.
• W1984938201 title "Immunoblot Analysis of the Seroreactivity to Recombinant <i>Borrelia burgdorferi </i>sensu lato Antigens, Including VlsE, in the Long-Term Course of Treated Patients with Erythema Migrans" @default.
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• W1984938201 doi "https://doi.org/10.1159/000111505" @default.
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