FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984949626> ?p ?o ?g. }

• W1984949626 abstract "Homozygous deletions in cancer cells have been thought to harbor tumor suppressor genes. We show that the 25 and 50 kb homozygous deletions in WWOX in the colon cancer cell line HCT116 result from a complex set of heterozygous deletions, some of which overlap to give homozygous loss. One of the heterozygous deletions has removed exons 6-8 of one allele of WWOX, and there is also a third copy of the distal region of WWOX in an unbalanced translocation. The exon 6-8 deletion results in allele-specific expression of a deleted transcript, which seems likely to be the main biological consequence of the deletions, since similar transcripts are found in other tumors. We show that such a complex set of deletions could form in a single exchange event between two homologous chromosomes, so that the selective advantage of such rearrangements need not be within the homozygous deletion. We conclude that homozygous deletions can be markers of complex rearrangements that have targets outside the homozygous deletion itself and that the target of deletions in the FRA16D region is indeed WWOX, the common outcome being the removal of particular WWOX exons. This article contains supplementary material available at http://www.interscience.wiley.com/jpages/1045-2257/suppmat." @default.
• W1984949626 created "2016-06-24" @default.
• W1984949626 creator A5025321863 @default.
• W1984949626 creator A5041323732 @default.
• W1984949626 creator A5059750212 @default.
• W1984949626 creator A5077035638 @default.
• W1984949626 creator A5079958715 @default.
• W1984949626 creator A5090639922 @default.
• W1984949626 date "2008-05-01" @default.
• W1984949626 modified "2023-10-03" @default.
• W1984949626 title "Homozygous deletions may be markers of nearby heterozygous mutations: The complex deletion atFRA16Din the HCT116 colon cancer cell line removes exons ofWWOX" @default.
• W1984949626 cites W114795016 @default.
• W1984949626 cites W180015230 @default.
• W1984949626 cites W1808157780 @default.
• W1984949626 cites W1973817726 @default.
• W1984949626 cites W1983348452 @default.
• W1984949626 cites W2006180279 @default.
• W1984949626 cites W2022462731 @default.
• W1984949626 cites W2022717702 @default.
• W1984949626 cites W2031837152 @default.
• W1984949626 cites W2048342209 @default.
• W1984949626 cites W2067714729 @default.
• W1984949626 cites W2081466880 @default.
• W1984949626 cites W2083436757 @default.
• W1984949626 cites W2087976729 @default.
• W1984949626 cites W2096259125 @default.
• W1984949626 cites W2099978872 @default.
• W1984949626 cites W2100522747 @default.
• W1984949626 cites W2101170189 @default.
• W1984949626 cites W2101693398 @default.
• W1984949626 cites W2126190124 @default.
• W1984949626 cites W2130679565 @default.
• W1984949626 cites W2131740501 @default.
• W1984949626 cites W2133174470 @default.
• W1984949626 cites W2135172903 @default.
• W1984949626 cites W2136683006 @default.
• W1984949626 cites W2139447006 @default.
• W1984949626 cites W2149115851 @default.
• W1984949626 cites W2151109134 @default.
• W1984949626 cites W2169462450 @default.
• W1984949626 cites W2315466277 @default.
• W1984949626 doi "https://doi.org/10.1002/gcc.20548" @default.
• W1984949626 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18273838" @default.
• W1984949626 hasPublicationYear "2008" @default.
• W1984949626 type Work @default.
• W1984949626 sameAs 1984949626 @default.
• W1984949626 citedByCount "20" @default.
• W1984949626 countsByYear W19849496262013 @default.
• W1984949626 countsByYear W19849496262014 @default.
• W1984949626 countsByYear W19849496262017 @default.
• W1984949626 countsByYear W19849496262019 @default.
• W1984949626 countsByYear W19849496262020 @default.
• W1984949626 countsByYear W19849496262021 @default.
• W1984949626 crossrefType "journal-article" @default.
• W1984949626 hasAuthorship W1984949626A5025321863 @default.
• W1984949626 hasAuthorship W1984949626A5041323732 @default.
• W1984949626 hasAuthorship W1984949626A5059750212 @default.
• W1984949626 hasAuthorship W1984949626A5077035638 @default.
• W1984949626 hasAuthorship W1984949626A5079958715 @default.
• W1984949626 hasAuthorship W1984949626A5090639922 @default.
• W1984949626 hasConcept C104317684 @default.
• W1984949626 hasConcept C127716648 @default.
• W1984949626 hasConcept C138626823 @default.
• W1984949626 hasConcept C143589142 @default.
• W1984949626 hasConcept C153911025 @default.
• W1984949626 hasConcept C179185449 @default.
• W1984949626 hasConcept C180754005 @default.
• W1984949626 hasConcept C206936463 @default.
• W1984949626 hasConcept C2778264664 @default.
• W1984949626 hasConcept C2780770488 @default.
• W1984949626 hasConcept C2909874657 @default.
• W1984949626 hasConcept C36823959 @default.
• W1984949626 hasConcept C501734568 @default.
• W1984949626 hasConcept C502942594 @default.
• W1984949626 hasConcept C54355233 @default.
• W1984949626 hasConcept C555283112 @default.
• W1984949626 hasConcept C86803240 @default.
• W1984949626 hasConceptScore W1984949626C104317684 @default.
• W1984949626 hasConceptScore W1984949626C127716648 @default.
• W1984949626 hasConceptScore W1984949626C138626823 @default.
• W1984949626 hasConceptScore W1984949626C143589142 @default.
• W1984949626 hasConceptScore W1984949626C153911025 @default.
• W1984949626 hasConceptScore W1984949626C179185449 @default.
• W1984949626 hasConceptScore W1984949626C180754005 @default.
• W1984949626 hasConceptScore W1984949626C206936463 @default.
• W1984949626 hasConceptScore W1984949626C2778264664 @default.
• W1984949626 hasConceptScore W1984949626C2780770488 @default.
• W1984949626 hasConceptScore W1984949626C2909874657 @default.
• W1984949626 hasConceptScore W1984949626C36823959 @default.
• W1984949626 hasConceptScore W1984949626C501734568 @default.
• W1984949626 hasConceptScore W1984949626C502942594 @default.
• W1984949626 hasConceptScore W1984949626C54355233 @default.
• W1984949626 hasConceptScore W1984949626C555283112 @default.
• W1984949626 hasConceptScore W1984949626C86803240 @default.
• W1984949626 hasLocation W19849496261 @default.
• W1984949626 hasLocation W19849496262 @default.
• W1984949626 hasOpenAccess W1984949626 @default.
• W1984949626 hasPrimaryLocation W19849496261 @default.
• W1984949626 hasRelatedWork W1759799165 @default.
• W1984949626 hasRelatedWork W1808157780 @default.

• next