FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984969864> ?p ?o ?g. }

• W1984969864 endingPage "e96608" @default.
• W1984969864 startingPage "e96608" @default.
• W1984969864 abstract "In multiple myeloma (MM), the malignant plasma cells usually localize to the bone marrow where they develop drug resistance due to adhesion to stromal cells and various environmental signals. Hence, modulation of this interaction is expected to influence drug sensitivity of MM cells. Toll-like receptor (TLR) ligands have displayed heterogeneous effects on B-cell malignancies and also on MM cells in a few recent studies, but effects on adhesion and drug sensitivity of myeloma cells in the context of bone marrow stromal cells (BMSCs) have never been investigated. In the present study, we explored the modulatory effects of TLR1/2 ligand (Pam3CSK4) on adhesion of human myeloma cells to BMSCs. It is shown that TLR1/2 triggering has opposite effects in different HMCLs on their adhesion to BMSCs. Fravel, L363, UM-6, UM-9 and U266 showed increased adhesion to BMSC in parallel with an increased surface expression of integrin molecules α4 and αVβ3. OPM-1, OPM-2 and NCI-H929 showed a dose-dependent decrease in adhesion upon TLR activation following a downregulation of β7 integrin expression. Importantly, TLR1/2 triggering increased cytotoxic and apoptotic effects of bortezomib in myeloma cells independent of the effect on stromal cell adhesion. Moreover, the apoptosis-enhancing effect of Pam3CSK4 paralleled induction of cleaved caspase-3 protein in FACS analysis suggesting a caspase-dependent mechanism. Our findings uncover a novel role of TLR activation in MM cells in the context of bone marrow microenvironment. Stimulation of TLR1/2 bypasses the protective shield of BMSCs and may be an interesting strategy to enhance drug sensitivity of multiple myeloma cells." @default.
• W1984969864 created "2016-06-24" @default.
• W1984969864 creator A5023267835 @default.
• W1984969864 creator A5047702224 @default.
• W1984969864 creator A5072624948 @default.
• W1984969864 creator A5080836916 @default.
• W1984969864 date "2014-05-02" @default.
• W1984969864 modified "2023-10-18" @default.
• W1984969864 title "Toll-Like Receptor (TLR)-1/2 Triggering of Multiple Myeloma Cells Modulates Their Adhesion to Bone Marrow Stromal Cells and Enhances Bortezomib-Induced Apoptosis" @default.
• W1984969864 cites W1519816848 @default.
• W1984969864 cites W1528751727 @default.
• W1984969864 cites W1723444490 @default.
• W1984969864 cites W1725655154 @default.
• W1984969864 cites W1852779802 @default.
• W1984969864 cites W1965428800 @default.
• W1984969864 cites W1976740602 @default.
• W1984969864 cites W1981276396 @default.
• W1984969864 cites W1984437179 @default.
• W1984969864 cites W1990518937 @default.
• W1984969864 cites W1994013901 @default.
• W1984969864 cites W1994108614 @default.
• W1984969864 cites W1999620129 @default.
• W1984969864 cites W2010552629 @default.
• W1984969864 cites W2015648217 @default.
• W1984969864 cites W2017614316 @default.
• W1984969864 cites W2023564006 @default.
• W1984969864 cites W2032975232 @default.
• W1984969864 cites W2034028219 @default.
• W1984969864 cites W2037183248 @default.
• W1984969864 cites W2040993067 @default.
• W1984969864 cites W2046056065 @default.
• W1984969864 cites W2047376205 @default.
• W1984969864 cites W2048199751 @default.
• W1984969864 cites W2052825822 @default.
• W1984969864 cites W2055229514 @default.
• W1984969864 cites W2058059173 @default.
• W1984969864 cites W2059873406 @default.
• W1984969864 cites W2060763507 @default.
• W1984969864 cites W2060982768 @default.
• W1984969864 cites W2067662036 @default.
• W1984969864 cites W2071752882 @default.
• W1984969864 cites W2073429790 @default.
• W1984969864 cites W2079513879 @default.
• W1984969864 cites W2093883160 @default.
• W1984969864 cites W2108968802 @default.
• W1984969864 cites W2109491705 @default.
• W1984969864 cites W2126120941 @default.
• W1984969864 cites W2126447600 @default.
• W1984969864 cites W2134823129 @default.
• W1984969864 cites W2156414024 @default.
• W1984969864 cites W2322800113 @default.
• W1984969864 cites W918634915 @default.
• W1984969864 doi "https://doi.org/10.1371/journal.pone.0096608" @default.
• W1984969864 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4008602" @default.
• W1984969864 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24794258" @default.
• W1984969864 hasPublicationYear "2014" @default.
• W1984969864 type Work @default.
• W1984969864 sameAs 1984969864 @default.
• W1984969864 citedByCount "15" @default.
• W1984969864 countsByYear W19849698642015 @default.
• W1984969864 countsByYear W19849698642016 @default.
• W1984969864 countsByYear W19849698642017 @default.
• W1984969864 countsByYear W19849698642018 @default.
• W1984969864 countsByYear W19849698642019 @default.
• W1984969864 countsByYear W19849698642020 @default.
• W1984969864 countsByYear W19849698642022 @default.
• W1984969864 crossrefType "journal-article" @default.
• W1984969864 hasAuthorship W1984969864A5023267835 @default.
• W1984969864 hasAuthorship W1984969864A5047702224 @default.
• W1984969864 hasAuthorship W1984969864A5072624948 @default.
• W1984969864 hasAuthorship W1984969864A5080836916 @default.
• W1984969864 hasBestOaLocation W19849698641 @default.
• W1984969864 hasConcept C1491633281 @default.
• W1984969864 hasConcept C151730666 @default.
• W1984969864 hasConcept C154317977 @default.
• W1984969864 hasConcept C16930146 @default.
• W1984969864 hasConcept C185592680 @default.
• W1984969864 hasConcept C202751555 @default.
• W1984969864 hasConcept C203014093 @default.
• W1984969864 hasConcept C2776364478 @default.
• W1984969864 hasConcept C2777478702 @default.
• W1984969864 hasConcept C2779343474 @default.
• W1984969864 hasConcept C2780007613 @default.
• W1984969864 hasConcept C502942594 @default.
• W1984969864 hasConcept C55493867 @default.
• W1984969864 hasConcept C85789140 @default.
• W1984969864 hasConcept C86803240 @default.
• W1984969864 hasConcept C95444343 @default.
• W1984969864 hasConceptScore W1984969864C1491633281 @default.
• W1984969864 hasConceptScore W1984969864C151730666 @default.
• W1984969864 hasConceptScore W1984969864C154317977 @default.
• W1984969864 hasConceptScore W1984969864C16930146 @default.
• W1984969864 hasConceptScore W1984969864C185592680 @default.
• W1984969864 hasConceptScore W1984969864C202751555 @default.
• W1984969864 hasConceptScore W1984969864C203014093 @default.
• W1984969864 hasConceptScore W1984969864C2776364478 @default.
• W1984969864 hasConceptScore W1984969864C2777478702 @default.
• W1984969864 hasConceptScore W1984969864C2779343474 @default.

• next