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- W1984976319 abstract "Digoxin was administered to normal CD-l mice (4 µg/kg per 24 hr), and the mice were inoculated intratracheally with Streptococcus pneumoniae in order to assess the effects of the cardiac glycosideon pulmonary antibacterial mechanisms. Digoxin-treated animals experienced a worse survival rate than did controls (19 of 50 versus 33 of 50; P < .01). When challenged with a high inoculum (1 × 106 cfu), animals given the glycoside demonstrated a significant impairment in their capacity to clear viable pneumococci from the lungs; the depression in pulmonary clearance was associated with a marked attenuation in the ability of digoxin-treated mice to recruit granulocytes and macrophages into the bronchoalveolar spaces. Following low inoculum challenge (1 × 105 cfu), animals treated with the cardiac glycoside exhibited an inefficient pulmonary clearance and a blunted macrophage influx. At clinically relevant concentrations, digoxin demonstrated no effect on the in vitro pneumococcidal activity of resident murine alveolar macrophages. We conclude that digoxin can disrupt host defense against pneumococcus by impeding the normal inflammatory response to organisms deposited into the lower respiratory tract." @default.
- W1984976319 created "2016-06-24" @default.
- W1984976319 creator A5070996133 @default.
- W1984976319 date "1985-07-01" @default.
- W1984976319 modified "2023-09-27" @default.
- W1984976319 title "Digoxin Disrupts the Inflammatory Response in Experimental Pneumococcal Pneumonia" @default.
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- W1984976319 doi "https://doi.org/10.1093/infdis/152.1.14" @default.
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