Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984980535> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W1984980535 endingPage "P171" @default.
- W1984980535 startingPage "P171" @default.
- W1984980535 abstract "Objective: A significant proportion of HNSCC is caused by human papillomavirus. Patients diagnosed with this subtype have a significantly better outcome. It is the aim of the UCL Head and Neck Cancer Epigenome Project to generate and analyze comprehensive, genome-wide profiles of epigenetic aberrations in this specific type of human cancer. Method: Whole-genome DNA methylation (methylome) analysis of 3 HPV positive and 3 HPV negative frozen HNSCC samples (obtained from the UCL Head and Neck Cancer Tissue Bank as part of a larger discovery set) was conducted using methylated DNA immunoprecipitation coupled with next-generation sequencing (MeDIP-Seq). Results: On average, each sample in the pilot phase generated 2 x 10 7 sequencing reads and 70% coverage of all CpG sites within the host genome. HPV type 16 was observed in all HPV positive samples and, interestingly, methylated regions of this virus were identified—most notably at genes E1 and L1 (previously shown to have been methylated in cervical cancer). We also detected multiple methylation changes between HPV positive and HPV negative host’s methylomes, of which a significant proportion mapped to genes previously shown to display down-regulated expression in transcriptionally active HPV positive oropharyngeal cancer. Conclusion: The observed epigenetic differences between the 2 types might explain the different clinical behavior of HPV-associated HNSCC. Although preliminary, these pilot data are encouraging with respect to the possibility of identifying potential diagnostic and prognostic markers, as well as putative therapeutic targets in this subtype of HNSCC." @default.
- W1984980535 created "2016-06-24" @default.
- W1984980535 creator A5017588786 @default.
- W1984980535 creator A5030821765 @default.
- W1984980535 creator A5038134476 @default.
- W1984980535 creator A5041076064 @default.
- W1984980535 creator A5046807661 @default.
- W1984980535 creator A5053316563 @default.
- W1984980535 creator A5059250730 @default.
- W1984980535 date "2011-08-01" @default.
- W1984980535 modified "2023-10-14" @default.
- W1984980535 title "Methylome Analysis of HPV-Associated Head and Neck Cancer" @default.
- W1984980535 doi "https://doi.org/10.1177/0194599811415823a121" @default.
- W1984980535 hasPublicationYear "2011" @default.
- W1984980535 type Work @default.
- W1984980535 sameAs 1984980535 @default.
- W1984980535 citedByCount "0" @default.
- W1984980535 crossrefType "journal-article" @default.
- W1984980535 hasAuthorship W1984980535A5017588786 @default.
- W1984980535 hasAuthorship W1984980535A5030821765 @default.
- W1984980535 hasAuthorship W1984980535A5038134476 @default.
- W1984980535 hasAuthorship W1984980535A5041076064 @default.
- W1984980535 hasAuthorship W1984980535A5046807661 @default.
- W1984980535 hasAuthorship W1984980535A5053316563 @default.
- W1984980535 hasAuthorship W1984980535A5059250730 @default.
- W1984980535 hasBestOaLocation W19849805351 @default.
- W1984980535 hasConcept C104317684 @default.
- W1984980535 hasConcept C116114238 @default.
- W1984980535 hasConcept C117717151 @default.
- W1984980535 hasConcept C121608353 @default.
- W1984980535 hasConcept C121912465 @default.
- W1984980535 hasConcept C140173407 @default.
- W1984980535 hasConcept C141231307 @default.
- W1984980535 hasConcept C143998085 @default.
- W1984980535 hasConcept C150194340 @default.
- W1984980535 hasConcept C190727270 @default.
- W1984980535 hasConcept C2776530083 @default.
- W1984980535 hasConcept C33288867 @default.
- W1984980535 hasConcept C41091548 @default.
- W1984980535 hasConcept C502942594 @default.
- W1984980535 hasConcept C54355233 @default.
- W1984980535 hasConcept C70721500 @default.
- W1984980535 hasConcept C71924100 @default.
- W1984980535 hasConcept C86803240 @default.
- W1984980535 hasConceptScore W1984980535C104317684 @default.
- W1984980535 hasConceptScore W1984980535C116114238 @default.
- W1984980535 hasConceptScore W1984980535C117717151 @default.
- W1984980535 hasConceptScore W1984980535C121608353 @default.
- W1984980535 hasConceptScore W1984980535C121912465 @default.
- W1984980535 hasConceptScore W1984980535C140173407 @default.
- W1984980535 hasConceptScore W1984980535C141231307 @default.
- W1984980535 hasConceptScore W1984980535C143998085 @default.
- W1984980535 hasConceptScore W1984980535C150194340 @default.
- W1984980535 hasConceptScore W1984980535C190727270 @default.
- W1984980535 hasConceptScore W1984980535C2776530083 @default.
- W1984980535 hasConceptScore W1984980535C33288867 @default.
- W1984980535 hasConceptScore W1984980535C41091548 @default.
- W1984980535 hasConceptScore W1984980535C502942594 @default.
- W1984980535 hasConceptScore W1984980535C54355233 @default.
- W1984980535 hasConceptScore W1984980535C70721500 @default.
- W1984980535 hasConceptScore W1984980535C71924100 @default.
- W1984980535 hasConceptScore W1984980535C86803240 @default.
- W1984980535 hasIssue "2_suppl" @default.
- W1984980535 hasLocation W19849805351 @default.
- W1984980535 hasOpenAccess W1984980535 @default.
- W1984980535 hasPrimaryLocation W19849805351 @default.
- W1984980535 hasRelatedWork W2041013779 @default.
- W1984980535 hasRelatedWork W2126769386 @default.
- W1984980535 hasRelatedWork W2142309127 @default.
- W1984980535 hasRelatedWork W2144727750 @default.
- W1984980535 hasRelatedWork W2152099406 @default.
- W1984980535 hasRelatedWork W2514614624 @default.
- W1984980535 hasRelatedWork W2570149195 @default.
- W1984980535 hasRelatedWork W2906103633 @default.
- W1984980535 hasRelatedWork W2936129299 @default.
- W1984980535 hasRelatedWork W4220682584 @default.
- W1984980535 hasVolume "145" @default.
- W1984980535 isParatext "false" @default.
- W1984980535 isRetracted "false" @default.
- W1984980535 magId "1984980535" @default.
- W1984980535 workType "article" @default.