Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984983337> ?p ?o ?g. }
- W1984983337 endingPage "63" @default.
- W1984983337 startingPage "56" @default.
- W1984983337 abstract "Using cultured proximal renal tubular epithelial cells (LLC-PK1), the present study investigates the effect of atrial natriuretic peptide (ANP) on cytotoxicity induced by cyclosporin A (CsA). Preincubation with ANP (1–100 nM) protected LLC-PK1 cells from CsA-induced toxicity in a concentration-dependent manner. A cytoprotective effect comparable to ANP was observed when preincubating the cells with 8-bromo cGMP (1–100 μM) or the antioxidant heme oxygenase (HO) metabolite bilirubin (0.1–10 μM). ANP or cGMP produced increases in HO-1 protein levels at concentrations that were also effective in cellular protection. Moreover, incubation with ANP or 8-bromo cGMP led to increased HO activity, i.e., formation of bilirubin in the cell lysate (up to 3-fold over basal). Tin protoporphyrin-IX (SnPP; 19 μM), an inhibitor of HO activity, completely abolished ANP-induced cytoprotection. Our results demonstrate that HO-1 is a cellular target of ANP and cGMP in renal cells. HO-1 induction and ensuing formation of antioxidant metabolites may be a novel pathway by which ANP protects from CsA-dependent nephrotoxicity and preserves renal function." @default.
- W1984983337 created "2016-06-24" @default.
- W1984983337 creator A5012217995 @default.
- W1984983337 creator A5030827133 @default.
- W1984983337 creator A5039683677 @default.
- W1984983337 creator A5042472192 @default.
- W1984983337 creator A5072636380 @default.
- W1984983337 creator A5076654859 @default.
- W1984983337 date "2002-01-01" @default.
- W1984983337 modified "2023-10-18" @default.
- W1984983337 title "Atrial natriuretic peptide reduces cyclosporin toxicity in renal cells: role of cGMP and heme oxygenase-1" @default.
- W1984983337 cites W1483926031 @default.
- W1984983337 cites W1486705747 @default.
- W1984983337 cites W1600690434 @default.
- W1984983337 cites W1629400406 @default.
- W1984983337 cites W1865602869 @default.
- W1984983337 cites W1939358434 @default.
- W1984983337 cites W1966582616 @default.
- W1984983337 cites W1978356536 @default.
- W1984983337 cites W1986872967 @default.
- W1984983337 cites W1987876550 @default.
- W1984983337 cites W1991052881 @default.
- W1984983337 cites W1991851525 @default.
- W1984983337 cites W1992071813 @default.
- W1984983337 cites W1994780914 @default.
- W1984983337 cites W1997276405 @default.
- W1984983337 cites W2016914332 @default.
- W1984983337 cites W2021669660 @default.
- W1984983337 cites W2033914311 @default.
- W1984983337 cites W2036289263 @default.
- W1984983337 cites W2037901930 @default.
- W1984983337 cites W2039705433 @default.
- W1984983337 cites W2042161264 @default.
- W1984983337 cites W2046658387 @default.
- W1984983337 cites W2048307931 @default.
- W1984983337 cites W2050268197 @default.
- W1984983337 cites W2057235545 @default.
- W1984983337 cites W2062655222 @default.
- W1984983337 cites W2065633930 @default.
- W1984983337 cites W2067739721 @default.
- W1984983337 cites W2071685889 @default.
- W1984983337 cites W2102121190 @default.
- W1984983337 cites W2115485369 @default.
- W1984983337 cites W2120505405 @default.
- W1984983337 cites W2123008059 @default.
- W1984983337 cites W2123045737 @default.
- W1984983337 cites W2145530136 @default.
- W1984983337 cites W2155742265 @default.
- W1984983337 cites W2157341713 @default.
- W1984983337 cites W2159279632 @default.
- W1984983337 cites W2472609569 @default.
- W1984983337 doi "https://doi.org/10.1016/s0891-5849(01)00761-4" @default.
- W1984983337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11755317" @default.
- W1984983337 hasPublicationYear "2002" @default.
- W1984983337 type Work @default.
- W1984983337 sameAs 1984983337 @default.
- W1984983337 citedByCount "46" @default.
- W1984983337 countsByYear W19849833372012 @default.
- W1984983337 countsByYear W19849833372013 @default.
- W1984983337 countsByYear W19849833372014 @default.
- W1984983337 countsByYear W19849833372015 @default.
- W1984983337 countsByYear W19849833372016 @default.
- W1984983337 countsByYear W19849833372021 @default.
- W1984983337 crossrefType "journal-article" @default.
- W1984983337 hasAuthorship W1984983337A5012217995 @default.
- W1984983337 hasAuthorship W1984983337A5030827133 @default.
- W1984983337 hasAuthorship W1984983337A5039683677 @default.
- W1984983337 hasAuthorship W1984983337A5042472192 @default.
- W1984983337 hasAuthorship W1984983337A5072636380 @default.
- W1984983337 hasAuthorship W1984983337A5076654859 @default.
- W1984983337 hasConcept C126189478 @default.
- W1984983337 hasConcept C126322002 @default.
- W1984983337 hasConcept C134018914 @default.
- W1984983337 hasConcept C178790620 @default.
- W1984983337 hasConcept C181199279 @default.
- W1984983337 hasConcept C185592680 @default.
- W1984983337 hasConcept C2776151105 @default.
- W1984983337 hasConcept C2776217839 @default.
- W1984983337 hasConcept C2777477808 @default.
- W1984983337 hasConcept C2777513400 @default.
- W1984983337 hasConcept C2778069365 @default.
- W1984983337 hasConcept C2779219270 @default.
- W1984983337 hasConcept C2780967304 @default.
- W1984983337 hasConcept C29730261 @default.
- W1984983337 hasConcept C55493867 @default.
- W1984983337 hasConcept C71924100 @default.
- W1984983337 hasConcept C86803240 @default.
- W1984983337 hasConcept C98274493 @default.
- W1984983337 hasConceptScore W1984983337C126189478 @default.
- W1984983337 hasConceptScore W1984983337C126322002 @default.
- W1984983337 hasConceptScore W1984983337C134018914 @default.
- W1984983337 hasConceptScore W1984983337C178790620 @default.
- W1984983337 hasConceptScore W1984983337C181199279 @default.
- W1984983337 hasConceptScore W1984983337C185592680 @default.
- W1984983337 hasConceptScore W1984983337C2776151105 @default.
- W1984983337 hasConceptScore W1984983337C2776217839 @default.
- W1984983337 hasConceptScore W1984983337C2777477808 @default.
- W1984983337 hasConceptScore W1984983337C2777513400 @default.