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• W1984983748 abstract "Early life programming has important consequences for future health and wellbeing. A key new aspect is the impact of perinatal light on the circadian system. Postnatal light environment will program circadian behavior, together with cell morphology and clock gene function within the suprachiasmatic nucleus (SCN) of the hypothalamus, the principal circadian clock in mammals. Nevertheless, it is still not clear whether the observed changes reflect a processing of an altered photic input from the retina, rather than an imprinting of the intrinsic molecular clock mechanisms. Here, we addressed the issue by systematically probing the mouse circadian system at various levels. Firstly, we used electroretinography, pupillometry and histology protocols to show that gross retinal function and morphology in the adult are largely independent of postnatal light experiences that modulate circadian photosensitivity. Secondly, we used circadian activity protocols to show that only the animal's behavioral responses to chronic light exposure, but not to constant darkness or the acute responses to a light stimulus depend on postnatal light experience. Thirdly, we used real-time PER2::LUC rhythm recording to show long-term changes in clock gene expression in the SCN, but also heart, lung and spleen. The data showed that perinatal light mainly targets the long-term adaptive responses of the circadian clock to environmental light, rather than the retina or intrinsic clock mechanisms. Finally, we found long-term effects on circadian peripheral clocks, suggesting far-reaching consequences for the animal's overall physiology." @default.
• W1984983748 created "2016-06-24" @default.
• W1984983748 creator A5018044829 @default.
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• W1984983748 date "2014-05-19" @default.
• W1984983748 modified "2023-09-23" @default.
• W1984983748 title "Programming of Mice Circadian Photic Responses by Postnatal Light Environment" @default.
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• W1984983748 doi "https://doi.org/10.1371/journal.pone.0097160" @default.
• W1984983748 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4026311" @default.
• W1984983748 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24842115" @default.
• W1984983748 hasPublicationYear "2014" @default.
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