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- W1984995799 abstract "The flavonolignan isosilybin (1) is one of the silybin congeners contained in the silymarin complex, which is isolated from the seeds of the milk thistle (Silybum marianum). A number of recent studies have demonstrated that isosilybin is probably the most potent anticancer agent found in silymarin. It occurs as a mixture of two diastereoisomers, A and B. Lipase Novozym 435 was found to allow the preparative production of both optically pure isosilybin A and B in a diastereoisomeric purity of over 95%. A preparatory method based on the enzymatic resolution and other purification methods has been developed, enabling multigram amounts of both optically pure isosilybins A (1a) and B (1b) to be obtained." @default.
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- W1984995799 date "2013-01-01" @default.
- W1984995799 modified "2023-10-17" @default.
- W1984995799 title "Preparative method for isosilybin isolation based on enzymatic kinetic resolution of silymarin mixture" @default.
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- W1984995799 doi "https://doi.org/10.1016/j.procbio.2012.11.006" @default.
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