Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984999956> ?p ?o ?g. }
- W1984999956 endingPage "81" @default.
- W1984999956 startingPage "71" @default.
- W1984999956 abstract "Over the last decade, the active role of the microenvironment in the pathogenesis of B cell lymphomas has been recognized, delivering signals that favor clonal expansion and drug resistance. We are only beginning to understand the complex cross talk between neoplastic B cells and the tissue microenvironment, for example in secondary lymphoid organs, but some key cellular and molecular players have emerged. Mesenchymal stromal cells, nurselike cells (NLC) and lymphoma-associated macrophages (LAM), in concert with T cells, natural killer cells and extracellular matrix components participate in the dialog with the neoplastic B cells. B cell receptor signaling, activation via TNF family members (i.e. BAFF, APRIL), and tissue homing chemokine receptors and adhesion molecules are important in the interaction between malignant B cells and their microenvironment. Disrupting this cross talk is an attractive novel strategy for treating patients with B cell malignancies. Here, we summarize the cellular and molecular interactions between B cell lymphoma/leukemia cells and their microenvironment, and the therapeutic targets that are emerging, focusing on small molecule inhibitors that are targeting B cell receptor-associated kinases SYK, BTK, and PI3Ks, as well as on immunomodulatory agents and T cell mediated therapies. Clinically relevant aspects of new targeted therapeutics will be discussed, along with an outlook into future therapeutic strategies." @default.
- W1984999956 created "2016-06-24" @default.
- W1984999956 creator A5058755419 @default.
- W1984999956 creator A5067154165 @default.
- W1984999956 date "2014-02-01" @default.
- W1984999956 modified "2023-10-04" @default.
- W1984999956 title "The microenvironment in chronic lymphocytic leukemia (CLL) and other B cell malignancies: Insight into disease biology and new targeted therapies" @default.
- W1984999956 cites W115619992 @default.
- W1984999956 cites W1490756864 @default.
- W1984999956 cites W1492263161 @default.
- W1984999956 cites W1498674633 @default.
- W1984999956 cites W1531083786 @default.
- W1984999956 cites W1759857471 @default.
- W1984999956 cites W1963522404 @default.
- W1984999956 cites W1964899672 @default.
- W1984999956 cites W1966657425 @default.
- W1984999956 cites W1968488884 @default.
- W1984999956 cites W1969487650 @default.
- W1984999956 cites W1970663543 @default.
- W1984999956 cites W1971436806 @default.
- W1984999956 cites W1971487921 @default.
- W1984999956 cites W1971505103 @default.
- W1984999956 cites W1972593274 @default.
- W1984999956 cites W1973379466 @default.
- W1984999956 cites W1976402300 @default.
- W1984999956 cites W1976767301 @default.
- W1984999956 cites W1976978160 @default.
- W1984999956 cites W1977395168 @default.
- W1984999956 cites W1978963403 @default.
- W1984999956 cites W1979543825 @default.
- W1984999956 cites W1979816280 @default.
- W1984999956 cites W1981103871 @default.
- W1984999956 cites W1982822355 @default.
- W1984999956 cites W1983395516 @default.
- W1984999956 cites W1984072004 @default.
- W1984999956 cites W1985565700 @default.
- W1984999956 cites W1989134497 @default.
- W1984999956 cites W1990765152 @default.
- W1984999956 cites W1991988527 @default.
- W1984999956 cites W1993192840 @default.
- W1984999956 cites W2004049801 @default.
- W1984999956 cites W2004801769 @default.
- W1984999956 cites W2006411367 @default.
- W1984999956 cites W2006608981 @default.
- W1984999956 cites W2007886976 @default.
- W1984999956 cites W2009593167 @default.
- W1984999956 cites W2011950935 @default.
- W1984999956 cites W2012228539 @default.
- W1984999956 cites W2014113929 @default.
- W1984999956 cites W2014246201 @default.
- W1984999956 cites W2014991225 @default.
- W1984999956 cites W2015816151 @default.
- W1984999956 cites W2018531061 @default.
- W1984999956 cites W2018756833 @default.
- W1984999956 cites W2019655196 @default.
- W1984999956 cites W2020586896 @default.
- W1984999956 cites W2021588881 @default.
- W1984999956 cites W2025786205 @default.
- W1984999956 cites W2026384230 @default.
- W1984999956 cites W2027839043 @default.
- W1984999956 cites W2027971058 @default.
- W1984999956 cites W2028140189 @default.
- W1984999956 cites W2028509107 @default.
- W1984999956 cites W2033048812 @default.
- W1984999956 cites W2033315156 @default.
- W1984999956 cites W2033849790 @default.
- W1984999956 cites W2034156576 @default.
- W1984999956 cites W2034400622 @default.
- W1984999956 cites W2035762640 @default.
- W1984999956 cites W2035916624 @default.
- W1984999956 cites W2036217549 @default.
- W1984999956 cites W2036758696 @default.
- W1984999956 cites W2037796411 @default.
- W1984999956 cites W2038053631 @default.
- W1984999956 cites W2040570751 @default.
- W1984999956 cites W2040585498 @default.
- W1984999956 cites W2040604274 @default.
- W1984999956 cites W2042626190 @default.
- W1984999956 cites W2043741078 @default.
- W1984999956 cites W2044627735 @default.
- W1984999956 cites W2046304104 @default.
- W1984999956 cites W2047647041 @default.
- W1984999956 cites W2049398130 @default.
- W1984999956 cites W2049910239 @default.
- W1984999956 cites W2051321376 @default.
- W1984999956 cites W2051549641 @default.
- W1984999956 cites W2051763289 @default.
- W1984999956 cites W2052397619 @default.
- W1984999956 cites W2052763184 @default.
- W1984999956 cites W2055568760 @default.
- W1984999956 cites W2058786179 @default.
- W1984999956 cites W2059178419 @default.
- W1984999956 cites W2062733828 @default.
- W1984999956 cites W2062832330 @default.
- W1984999956 cites W2065338378 @default.
- W1984999956 cites W2066373927 @default.
- W1984999956 cites W2067257663 @default.
- W1984999956 cites W2068335535 @default.