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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985008686> ?p ?o ?g. }

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• W1985008686 abstract "In Caenorhabditis elegans , pre-mRNA for the essential splicing factor U2AF 65 sometimes is spliced to produce an RNA that includes an extra 216-bp internal exon, exon 3. Inclusion of exon 3 inserts an in-frame stop codon, yet this RNA is not subject to SMG-mediated RNA surveillance. To test whether exon 3 causes RNA to remain nuclear and thereby escape decay, we inserted it into the 3′ untranslated region of a gfp reporter gene. Although exon 3 did not affect accumulation or processing of the mRNA, it dramatically suppressed expression of green fluorescent protein (GFP). We showed by in situ hybridization that exon 3-containing gfp RNA is retained in the nucleus. Intriguingly, exon 3 contains 10 matches to the 8-bp 3′ splice-site consensus. We hypothesized that U2AF might recognize this octamer and thereby prevent export. This idea is supported by RNA interference experiments in which reduced levels of U2AF resulted in a small burst of gfp expression." @default.
• W1985008686 created "2016-06-24" @default.
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• W1985008686 date "1999-03-30" @default.
• W1985008686 modified "2023-10-16" @default.
• W1985008686 title "An exon that prevents transport of a mature mRNA" @default.
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• W1985008686 doi "https://doi.org/10.1073/pnas.96.7.3813" @default.
• W1985008686 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/22377" @default.
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