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• W1985008712 abstract "Several investigators studied whether the endothelial release of nitric oxide (NO) deteriorates in patients with coronary spastic angina; however, the answer to this important question remains controversial. 1 Kugiyama K Yasue H Okumura K Ogawa H Fujimoto K Nakao K Yoshimura M Motoyama T Inoue Y Kawano H Nitric oxide activity is deficient in spasm arteries of patients with coronary spastic angina. Circulation. 1996; 94: 266-272 Crossref PubMed Scopus (343) Google Scholar , 2 Egashira K Katsuda Y Mohri M Kuga T Tagawa T Shimokawa H Takeshita A Basal release of nitric oxide at site of spasm in patients with variant angina. J Am Coll Cardiol. 1996; 27: 1444-1449 Abstract Full Text PDF PubMed Scopus (49) Google Scholar We recently reported a study demonstrating the release of serotonin from platelets across the coronary bed during the nonattack period in patients with coronary spastic angina. 3 Murakami Y Ishinaga Y Sano K Murakami R Kinoshita Y Kitamura J Kobayashi K Okada S Matsubara K Shimada T Increased serotonin release across the coronary bed during a nonischemic interval in patients with vasospastic angina. Clin Cardiol. 1996; 19: 473-476 Crossref PubMed Scopus (22) Google Scholar Serotonin binds to serotonin receptors and enhances NO production via the L-arginine-NO synthase pathway. 4 Kaumann A.J Frenken M Posival H Brown A.M Variable participation of 5-HT1-like receptors and 5-HT2 receptors in serotonin-induced contraction on human isolated coronary arteries. 5-HT1-like receptors resemble cloned 5-HT1Dβ receptors. Circulation. 1994; 90: 1141-1153 Crossref PubMed Scopus (168) Google Scholar , 5 Vanhoutte P.M Platelet-derived serotonin, the endothelium, and cardiovascular disease. J Cardiovasc Pharmacol. 1991; 17: S6-S12 PubMed Google Scholar Previous reports investigated endothelial function using coronary diameter measurements after NO synthase blockade. 1 Kugiyama K Yasue H Okumura K Ogawa H Fujimoto K Nakao K Yoshimura M Motoyama T Inoue Y Kawano H Nitric oxide activity is deficient in spasm arteries of patients with coronary spastic angina. Circulation. 1996; 94: 266-272 Crossref PubMed Scopus (343) Google Scholar , 2 Egashira K Katsuda Y Mohri M Kuga T Tagawa T Shimokawa H Takeshita A Basal release of nitric oxide at site of spasm in patients with variant angina. J Am Coll Cardiol. 1996; 27: 1444-1449 Abstract Full Text PDF PubMed Scopus (49) Google Scholar Simultaneous measurements of serotonin and nitrate/nitrite (NOx) may be useful as a different approach to evaluation of endothelial function in patients with coronary spastic angina. The specific goal of this study is to evaluate whether the endothelial release of NO in response to serotonin is impaired in patients with coronary spastic angina." @default.
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• W1985008712 date "1999-03-01" @default.
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• W1985008712 title "Impairment of serotonin-mediated nitric oxide release across the coronary bed in patients with coronary spastic angina" @default.
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• W1985008712 doi "https://doi.org/10.1016/s0002-9149(98)01054-6" @default.
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