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• W1985010122 endingPage "373" @default.
• W1985010122 startingPage "366" @default.
• W1985010122 abstract "Fenofibrate (FBT) is lipophillic drug used in hypercholesterolemia and hypertriglyceridemia having log P 5.375, low solubility (practically insoluble in water) and low oral bioavailability (36%). The purpose of work was to develop FBT nanocrystals for the enhancement of solubility and oral bioavailability. Fenofibrate nanosuspension was prepared using probe sonicator and transformed into dry powder using freeze drying and characterized by DSC, FTIR, XRPD, SEM, particle size, polydispersity index (PDI), zeta potential, solubility, in vitro dissolution, in vivo bioavailability and stability studies. Formulation FNS3 and pure drug exhibited the in vitro dissolution about 73.89% and 8.53% in 1% sodium lauryl sulfate (SLS) media, respectively. When the particle size reduced from 80,000 ± 923 nm to 460 ± 20 nm, saturation solubility was significantly increased. The saturation solubility of formulation FNS3 in 0.5% and 1% of SLS media found to be 67.51 ± 1.5 μg/mL and 107 ± 1.9 μg/mL, respectively. While, the saturation solubility of pure drug in 0.5% and 1% of SLS was found to be 6.02 ± 1.51 μg/ml and 23.54 ± 1.54 μg/ml, respectively. The pharmacokinetic study of optimized nanocrystals (FNS3) conducted in New Zealand white rabbits showed 4.73-fold increase in relative bioavailability than that of pure drug. Long term stability studies showed that there was no significant change in the mean particle size and PDI at 5 °C ± 3 °C after 180 days. This enhanced dissolution and bioavailability of fenofibrate nanocrystals could be the promising approach for oral delivery." @default.
• W1985010122 created "2016-06-24" @default.
• W1985010122 creator A5044715280 @default.
• W1985010122 creator A5053276579 @default.
• W1985010122 creator A5076237479 @default.
• W1985010122 date "2013-08-01" @default.
• W1985010122 modified "2023-09-26" @default.
• W1985010122 title "Fabrication of fenofibrate nanocrystals by probe sonication method for enhancement of dissolution rate and oral bioavailability" @default.
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• W1985010122 doi "https://doi.org/10.1016/j.colsurfb.2013.02.043" @default.
• W1985010122 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23602990" @default.
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