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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985010135> ?p ?o ?g. }

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• W1985010135 abstract "Xanthohumol (XN), a prenylated chalcone present in hops (Humulus lupus L.) and beer, exhibits anti-inflammatory, antioxidant and antiproliferative activity, but has not been studied for effects on T cell-mediated immune responses. Here we demonstrate that XN has profound immunosuppressive effects on T cell proliferation, development of IL-2 activated killer (LAK) cells, cytotoxic T lymphocytes (CTLs), and production of Th1 cytokines (IL-2, IFN-γ and TNF-α). The suppression of these cell-mediated immune responses by XN was at, least in part, due to the inhibition of nuclear factor kappa B (NF-κB) transcription factor through suppression of phosphorylation of IκBα, an inhibitor of NF-κB." @default.
• W1985010135 created "2016-06-24" @default.
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• W1985010135 date "2009-04-21" @default.
• W1985010135 modified "2023-09-23" @default.
• W1985010135 title "Immunomodulatory activity of xanthohumol: inhibition of T cell proliferation, cell-mediated cytotoxicity and Th1 cytokine production through suppression of NF-κB" @default.
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• W1985010135 doi "https://doi.org/10.1080/08923970902798132" @default.
• W1985010135 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2759314" @default.
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