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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985012670> ?p ?o ?g. }

• W1985012670 endingPage "1986" @default.
• W1985012670 startingPage "1981" @default.
• W1985012670 abstract "Paclitaxel (Taxol), an effective anticancer agent, is known to bind to tubulin and induce tubulin polymerization. Several other binding proteins of paclitaxel, such as Bcl-2, heat shock proteins, and NSC-1, have also been reported. Here, we describe a T7 phage-based display to screen for paclitaxel-binding molecules from a random peptide library using paclitaxel-photoimmobilized TentaGel resin. Specific phage particles that bind the paclitaxel-immobilized resin were obtained. Among them, two phage clones included the same consensus amino acid sequence (KACGRTRVTS). Analysis of the protein database using BLAST revealed that a portion of this sequence is conserved in the zinc finger domain of human NFX1. Binding affinity of paclitaxel against the partial recombinant protein of NFX1 (424aa-876aa) was confirmed by pull-down assays and surface plasmon resonance analyses." @default.
• W1985012670 created "2016-06-24" @default.
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• W1985012670 date "2007-11-01" @default.
• W1985012670 modified "2023-09-30" @default.
• W1985012670 title "Screening of Paclitaxel-Binding Molecules from a Library of Random Peptides Displayed on T7 Phage Particles Using Paclitaxel-Photoimmobilized Resin" @default.
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• W1985012670 doi "https://doi.org/10.1021/bc700287v" @default.
• W1985012670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17979224" @default.
• W1985012670 hasPublicationYear "2007" @default.
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