FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985012922> ?p ?o ?g. }

• W1985012922 endingPage "1307" @default.
• W1985012922 startingPage "1299" @default.
• W1985012922 abstract "In this study, we compared immunoglobulin heavy-chain-gene-based minimal residual disease (MRD) detection by real-time quantitative PCR (RQ-PCR) and next-generation sequencing (NGS) to assess whether NGS could overcome some limitations of RQ-PCR and further increase sensitivity, specificity, accuracy and reproducibility. In total, 378 samples from 55 patients with acute lymphoblastic leukemia (ALL), mantle cell lymphoma (MCL) or multiple myeloma (MM) were investigated for clonotype identification, clonotype identity and comparability of MRD results. Forty-five clonotypes were identified by RQ-PCR and 49 by NGS. Clonotypes identified by both tools were identical or >97% homologous in 96% of cases. Both tools were able to routinely reach a sensitivity level of 1 × E-05. A good correlation of MRD results was observed (R=0.791, P<0.001), with excellent concordance in 79.6% of cases. Few discordant cases were observed across all disease subtypes. NGS showed at least the same level of sensitivity as allele-specific oligonucleotides-PCR, without the need for patient-specific reagents. We conclude that NGS is an effective tool for MRD monitoring in ALL, MCL and MM. Prospective comparative analysis of unselected cases is required to validate the clinical impact of NGS-based MRD assessment." @default.
• W1985012922 created "2016-06-24" @default.
• W1985012922 creator A5002571777 @default.
• W1985012922 creator A5012645361 @default.
• W1985012922 creator A5018139001 @default.
• W1985012922 creator A5035277761 @default.
• W1985012922 creator A5036916107 @default.
• W1985012922 creator A5039333571 @default.
• W1985012922 creator A5045286139 @default.
• W1985012922 creator A5056141793 @default.
• W1985012922 creator A5059967673 @default.
• W1985012922 creator A5064631593 @default.
• W1985012922 creator A5067318724 @default.
• W1985012922 creator A5071552171 @default.
• W1985012922 creator A5072819543 @default.
• W1985012922 creator A5075073484 @default.
• W1985012922 creator A5076353357 @default.
• W1985012922 creator A5077947210 @default.
• W1985012922 creator A5087781254 @default.
• W1985012922 date "2013-12-17" @default.
• W1985012922 modified "2023-10-15" @default.
• W1985012922 title "Next-generation sequencing and real-time quantitative PCR for minimal residual disease detection in B-cell disorders" @default.
• W1985012922 cites W1502322024 @default.
• W1985012922 cites W1967348190 @default.
• W1985012922 cites W1972308638 @default.
• W1985012922 cites W1976195576 @default.
• W1985012922 cites W1977921909 @default.
• W1985012922 cites W1981648274 @default.
• W1985012922 cites W1989485003 @default.
• W1985012922 cites W1998660089 @default.
• W1985012922 cites W2017785657 @default.
• W1985012922 cites W2019612632 @default.
• W1985012922 cites W2020094108 @default.
• W1985012922 cites W2028286166 @default.
• W1985012922 cites W2034592954 @default.
• W1985012922 cites W2039642633 @default.
• W1985012922 cites W2040208354 @default.
• W1985012922 cites W2041469840 @default.
• W1985012922 cites W2050152294 @default.
• W1985012922 cites W2052911603 @default.
• W1985012922 cites W2065464657 @default.
• W1985012922 cites W2071899049 @default.
• W1985012922 cites W2078124251 @default.
• W1985012922 cites W2095893307 @default.
• W1985012922 cites W2100025372 @default.
• W1985012922 cites W2109388187 @default.
• W1985012922 cites W2120654010 @default.
• W1985012922 cites W2122048891 @default.
• W1985012922 cites W2124235514 @default.
• W1985012922 cites W2144300368 @default.
• W1985012922 cites W2146909892 @default.
• W1985012922 cites W2148631711 @default.
• W1985012922 cites W2152996672 @default.
• W1985012922 cites W2159397371 @default.
• W1985012922 cites W2159853837 @default.
• W1985012922 cites W2168109746 @default.
• W1985012922 cites W2169269721 @default.
• W1985012922 cites W2321011524 @default.
• W1985012922 cites W303443004 @default.
• W1985012922 doi "https://doi.org/10.1038/leu.2013.375" @default.
• W1985012922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24342950" @default.
• W1985012922 hasPublicationYear "2013" @default.
• W1985012922 type Work @default.
• W1985012922 sameAs 1985012922 @default.
• W1985012922 citedByCount "249" @default.
• W1985012922 countsByYear W19850129222014 @default.
• W1985012922 countsByYear W19850129222015 @default.
• W1985012922 countsByYear W19850129222016 @default.
• W1985012922 countsByYear W19850129222017 @default.
• W1985012922 countsByYear W19850129222018 @default.
• W1985012922 countsByYear W19850129222019 @default.
• W1985012922 countsByYear W19850129222020 @default.
• W1985012922 countsByYear W19850129222021 @default.
• W1985012922 countsByYear W19850129222022 @default.
• W1985012922 countsByYear W19850129222023 @default.
• W1985012922 crossrefType "journal-article" @default.
• W1985012922 hasAuthorship W1985012922A5002571777 @default.
• W1985012922 hasAuthorship W1985012922A5012645361 @default.
• W1985012922 hasAuthorship W1985012922A5018139001 @default.
• W1985012922 hasAuthorship W1985012922A5035277761 @default.
• W1985012922 hasAuthorship W1985012922A5036916107 @default.
• W1985012922 hasAuthorship W1985012922A5039333571 @default.
• W1985012922 hasAuthorship W1985012922A5045286139 @default.
• W1985012922 hasAuthorship W1985012922A5056141793 @default.
• W1985012922 hasAuthorship W1985012922A5059967673 @default.
• W1985012922 hasAuthorship W1985012922A5064631593 @default.
• W1985012922 hasAuthorship W1985012922A5067318724 @default.
• W1985012922 hasAuthorship W1985012922A5071552171 @default.
• W1985012922 hasAuthorship W1985012922A5072819543 @default.
• W1985012922 hasAuthorship W1985012922A5075073484 @default.
• W1985012922 hasAuthorship W1985012922A5076353357 @default.
• W1985012922 hasAuthorship W1985012922A5077947210 @default.
• W1985012922 hasAuthorship W1985012922A5087781254 @default.
• W1985012922 hasBestOaLocation W19850129221 @default.
• W1985012922 hasConcept C104317684 @default.
• W1985012922 hasConcept C126322002 @default.
• W1985012922 hasConcept C143998085 @default.
• W1985012922 hasConcept C160798450 @default.

• next