Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985014642> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W1985014642 endingPage "369" @default.
- W1985014642 startingPage "361" @default.
- W1985014642 abstract "The mechanism of vesication from sulfur mustard remains unknown in spite of 80 years of investigation. We recently reported sulfur mustard–related inhibition of one or more protein (serine/threonine) phosphatases in tissue cytosol in vitro, suggesting a mechanism common to other vesicants such as cantharidin and Lewisite. Our investigation showed that this inhibition was related to the concentration of 2,2′-thiobis-ethanol (thiodiglycol), the hydrolysis product of sulfur mustard, rather than to the concentration of mustard itself. Related work showed an increase in the rate of NAD (but not NADP) reduction upon the addition of thiodiglycol to mouse liver cytosol. This result provided evidence that metabolism beyond thiodiglycol may be contributing to protein phosphatase inhibition. This observation indicated that metabolism involving one or more dehydrogenases may be necessary to produce the ultimate inhibitor of the protein phosphatases. We report here that thiodiglycol is a substrate for horse liver alcohol dehydrogenase (Km = 3.68 ± 0.45 mM and Vmax = 0.22 ± 0.01 μmol min−1 mg protein−1) and for pyridine nucleotide-linked enzymes in mouse liver and human skin cytosol. The alcohol dehydrogenase-specific inhibitor 4-methylpyrazole inhibited the oxidation of thiodiglycol by the pure horse liver enzyme as well as by the enzymes in human skin and mouse liver cytosol, indicating that the activity in the tissue preparations is also alcohol dehydrogenase. © 1998 John Wiley & Sons, Inc. J Biochem Mol Toxicol 12: 361–369, 1998" @default.
- W1985014642 created "2016-06-24" @default.
- W1985014642 creator A5000333259 @default.
- W1985014642 creator A5008006547 @default.
- W1985014642 creator A5054366496 @default.
- W1985014642 creator A5061958507 @default.
- W1985014642 date "1998-01-01" @default.
- W1985014642 modified "2023-09-23" @default.
- W1985014642 title "In vitro oxidation of the hydrolysis product of sulfur mustard, 2,2?-thiobis-ethanol, by mammalian alcohol dehydrogenase" @default.
- W1985014642 doi "https://doi.org/10.1002/(sici)1099-0461(1998)12:6<361::aid-jbt6>3.0.co;2-z" @default.
- W1985014642 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9736485" @default.
- W1985014642 hasPublicationYear "1998" @default.
- W1985014642 type Work @default.
- W1985014642 sameAs 1985014642 @default.
- W1985014642 citedByCount "16" @default.
- W1985014642 countsByYear W19850146422012 @default.
- W1985014642 countsByYear W19850146422013 @default.
- W1985014642 countsByYear W19850146422015 @default.
- W1985014642 countsByYear W19850146422017 @default.
- W1985014642 countsByYear W19850146422018 @default.
- W1985014642 crossrefType "journal-article" @default.
- W1985014642 hasAuthorship W1985014642A5000333259 @default.
- W1985014642 hasAuthorship W1985014642A5008006547 @default.
- W1985014642 hasAuthorship W1985014642A5054366496 @default.
- W1985014642 hasAuthorship W1985014642A5061958507 @default.
- W1985014642 hasConcept C178666793 @default.
- W1985014642 hasConcept C178790620 @default.
- W1985014642 hasConcept C181199279 @default.
- W1985014642 hasConcept C185592680 @default.
- W1985014642 hasConcept C2776414213 @default.
- W1985014642 hasConcept C2777344606 @default.
- W1985014642 hasConcept C2780161600 @default.
- W1985014642 hasConcept C2780644109 @default.
- W1985014642 hasConcept C2780906345 @default.
- W1985014642 hasConcept C29730261 @default.
- W1985014642 hasConcept C55493867 @default.
- W1985014642 hasConcept C62231903 @default.
- W1985014642 hasConcept C75520062 @default.
- W1985014642 hasConcept C98539663 @default.
- W1985014642 hasConceptScore W1985014642C178666793 @default.
- W1985014642 hasConceptScore W1985014642C178790620 @default.
- W1985014642 hasConceptScore W1985014642C181199279 @default.
- W1985014642 hasConceptScore W1985014642C185592680 @default.
- W1985014642 hasConceptScore W1985014642C2776414213 @default.
- W1985014642 hasConceptScore W1985014642C2777344606 @default.
- W1985014642 hasConceptScore W1985014642C2780161600 @default.
- W1985014642 hasConceptScore W1985014642C2780644109 @default.
- W1985014642 hasConceptScore W1985014642C2780906345 @default.
- W1985014642 hasConceptScore W1985014642C29730261 @default.
- W1985014642 hasConceptScore W1985014642C55493867 @default.
- W1985014642 hasConceptScore W1985014642C62231903 @default.
- W1985014642 hasConceptScore W1985014642C75520062 @default.
- W1985014642 hasConceptScore W1985014642C98539663 @default.
- W1985014642 hasIssue "6" @default.
- W1985014642 hasLocation W19850146421 @default.
- W1985014642 hasLocation W19850146422 @default.
- W1985014642 hasOpenAccess W1985014642 @default.
- W1985014642 hasPrimaryLocation W19850146421 @default.
- W1985014642 hasRelatedWork W1975954498 @default.
- W1985014642 hasRelatedWork W1977200340 @default.
- W1985014642 hasRelatedWork W2011904545 @default.
- W1985014642 hasRelatedWork W2042023986 @default.
- W1985014642 hasRelatedWork W2064414270 @default.
- W1985014642 hasRelatedWork W2090074319 @default.
- W1985014642 hasRelatedWork W2412195954 @default.
- W1985014642 hasRelatedWork W2415384603 @default.
- W1985014642 hasRelatedWork W4289973992 @default.
- W1985014642 hasRelatedWork W58915465 @default.
- W1985014642 hasVolume "12" @default.
- W1985014642 isParatext "false" @default.
- W1985014642 isRetracted "false" @default.
- W1985014642 magId "1985014642" @default.
- W1985014642 workType "article" @default.