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- W1985022778 abstract "Cytosolic phospholipase A2 (cPLA2) plays an important role in the stimulus-dependent hydrolysis of sn-2 ester bond from membrane phospholipids, releasing arachidonic acid (AA), which along with its metabolites is involved in a number of regulatory functions. The present study examined the effect of methylmercury (MeHg; 0, 2.5, 5.0 μM) on cPLA2 activation in primary hippocampal neurons by assessing the release of 3H-AA. A significant increase in AA release was observed in cultures treated with 5 μM MeHg (10, 30, 60 and 120 min). This effect was due to neuronal cPLA2 activation, since it was completely abolished by arachidonyl trifluoromethyl ketone (AACOCF3), a specific inhibitor of cPLA2. Additional studies confirmed, by means of western blot analysis, that MeHg (5.0 and 10 μM; 16 h) potently increases neuronal cPLA2 protein expression. These results suggest that cPLA2-stimulated hydrolysis and release of AA are potential mediators of MeHg-induced neurotoxicity." @default.
- W1985022778 created "2016-06-24" @default.
- W1985022778 creator A5014818977 @default.
- W1985022778 creator A5035503566 @default.
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- W1985022778 date "2004-03-01" @default.
- W1985022778 modified "2023-10-16" @default.
- W1985022778 title "Methylmercury Stimulates Arachidonic Acid Release and Cytosolic Phospholipase A2 Expression in Primary Neuronal Cultures" @default.
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- W1985022778 doi "https://doi.org/10.1016/j.neuro.2003.08.008" @default.
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