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- W1985027171 startingPage "101" @default.
- W1985027171 abstract "Psoriasis and psoriatic arthritis are immune disorders with a complex polygenic basis. HLA-Cw6, which lies in the major histocompatibility region on chromosome 6, is considered the major genetic determinant of psoriasis. Recent genome-wide association studies have identified new variants outside of the MHC with relevance to the immunology of psoriasis. Variants in or near genes that encode subunits of cytokines (IL12B, IL23A) or cytokine receptors (IL23R) are interesting given that the gene product of IL12B, p40, is the target of a recently approved monoclonal antibody therapy for psoriasis (ustekinumab). Association with psoriasis and psoriatic arthritis has been found in TNFAIP3 and TNFIP1, ubiquitin ligases in the NF-κB pathway, and IL13, a Th2 cytokine. Copy number variation of human beta-defensin and late cornified envelope genes also associate with psoriasis. Many of these genetic variations also associate with immune disorders considered psoriatic co-morbidities, including Crohn's disease and diabetes." @default.
- W1985027171 created "2016-06-24" @default.
- W1985027171 creator A5028156662 @default.
- W1985027171 creator A5040462381 @default.
- W1985027171 creator A5063001450 @default.
- W1985027171 date "2010-03-01" @default.
- W1985027171 modified "2023-09-27" @default.
- W1985027171 title "Genetic variations associated with psoriasis and psoriatic arthritis found by genome-wide association" @default.
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