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• W1985027598 endingPage "141" @default.
• W1985027598 startingPage "133" @default.
• W1985027598 abstract "Dietary factors affecting tissue storage of beta-carotene (BC), alpha-tocopherol (alpha-T), and retinol (ROL) in mammals include taurocholate, protein, and fat. Few studies have examined the effects of these factors on the storage of BC, retinyl esters, and alpha-T in a mammalian system that is similar to humans. The main objective of the study was to investigate the effects of taurocholate (TC), fat, and protein on the absorption and metabolism of BC and alpha-T in ferret tissues. Three 4-week experiments were conducted using groups of 5–6 ferrets per treatment. All diets contained 0.2% BC. In Experiment 1, taurocholate was fed at concentrations of 0, 0.5, or 1%. Effects of two concentrations of dietary fat (6 and 23%) and three concentrations of protein (10, 20, and 40%) were also studied in Experiments 2 and 3, respectively. Tissues were analyzed for BC, retinoids, and alpha-T by high-pressure liquid chromatography (HPLC). Taurocholate enhanced hepatic and plasma concentrations of BC (2.3- to 3-fold), retinyl palmitate [(RP) 3.2- to 9.5-fold], retinyl stearate [(RS) 2.9- to 6- fold], and hepatic alpha-T (6- to13- fold) at p < 0.05. High-fat diets elevated hepatic BC, RP, RS, and retinyl linoleate (RL) concentrations (2- to 3.6-fold, p < 0.05). In contrast, high-protein diets lowered hepatic RL 1.8-fold and alpha-T 8-fold (p < 0.05). Our results indicate the importance of taurocholate, fat, and protein in achieving adequate levels of vitamins A and E in mammals." @default.
• W1985027598 created "2016-06-24" @default.
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• W1985027598 date "2005-03-01" @default.
• W1985027598 modified "2023-09-23" @default.
• W1985027598 title "Effects of Dietary Taurocholate, Fat and Protein on the Storage and Metabolism of Dietary beta-Carotene and alpha-Tocopherol in Ferrets" @default.
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• W1985027598 doi "https://doi.org/10.1024/0300-9831.75.2.133" @default.
• W1985027598 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15929634" @default.
• W1985027598 hasPublicationYear "2005" @default.
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