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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985029443> ?p ?o ?g. }

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• W1985029443 abstract "Scavenger receptor associated with endothelial cells (SREC-I) was previously shown to be expressed by immune cells and to play a role in CD8 + -mediated T cell immunity . SREC-I was also shown to modulate the function of Toll like receptors with essential roles in innate immunity . Here we have shown that SREC-I enhanced double stranded RNA (dsRNA)-mediated Toll like receptor-3 (TLR3) activation. Viral double stranded RNA (dsRNA) was demonstrated to be a pathogen associated molecular pattern (PAMP) signaling viral infection. We found that in human monocyte/macrophage THP1 cells as well as murine bone marrow derived macrophages SREC-I led to elevated responses to the dsRNA-like molecule polyinosine–polycytidylic acid (Poly I:C) and enhanced production of inflammatory cytokines. Our data also showed that intracellular/endocytic TLR3 could directly interact with SREC-I in the presence of Poly I:C. The internalized ligand, along with TLR3 and SREC-I localized in endosomes within macrophages and in HEK293 cells engineered to express TLR3 and SREC-I. SREC-I also stimulated dsRNA-mediated TLR3 activation of signaling through the NFκβ, MAP kinase and interferon regulatory factor 3 (IRF3) pathways leading to expression of cytokines, most notably interleukin-8 and interferon-β. We therefore hypothesized that SREC-I could be a receptor capable of internalizing Poly I:C, boosting TLR3 mediated inflammatory signaling and stimulating cytokine production in macrophages." @default.
• W1985029443 created "2016-06-24" @default.
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• W1985029443 date "2015-06-01" @default.
• W1985029443 modified "2023-10-15" @default.
• W1985029443 title "Scavenger receptor SREC-I promotes double stranded RNA-mediated TLR3 activation in human monocytes" @default.
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• W1985029443 doi "https://doi.org/10.1016/j.imbio.2014.12.011" @default.
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