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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985058770> ?p ?o ?g. }

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• W1985058770 abstract "The mechanism by which extracellular alkalosis inhibits hypoxic pulmonary vasoconstriction is unknown. We investigated whether the inhibition was due to intrapulmonary production of a vasodilator prostaglandin such as prostacyclin (PGI2). Hypoxic vasoconstriction in isolated salt-solution-perfused rat lungs was blunted by both hypocapnic and NaHCO3_induced alkalosis (perfusate pH increased from 7.3 to 7.7). The NaHCO3-induced alkalosis was accompanied by a significant increase in the perfusate level of 6-keto-prostaglandin F1α (6-keto-PGF1α), an hydrolysis product of PGI1. Meclofenamate, an inhibitor of cyclooxygenase, counteracted both the blunting of hypoxic vasoconstriction and the increased level of 6-keto-PGF1α. In intact anesthetized dogs, hypocapnic alkalosis (blood pH increased from 7.4 to 7.5) blunted hypoxic pulmonary vasoconstriction before but not after administration of meclofenamate. In separate cultures of bovine pulmonary artery endothelial and smooth muscle cells stimulated by bradykinin, the incubation medium levels of 6-keto-PGF1α were increased by both hypocapnia and NaHCO3-induced alkalosis (medium pH increased from 7.4 to 7.7). These results suggest that inhibition of hypoxic pulmonary vasoconstriction by alkalosis is mediated at least partly by PGI2." @default.
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• W1985058770 date "1989-07-01" @default.
• W1985058770 modified "2023-10-12" @default.
• W1985058770 title "Prostacyclin contributes to inhibition of hypoxic pulmonary vasoconstriction by alkalosis" @default.
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• W1985058770 doi "https://doi.org/10.1016/0090-6980(89)90016-6" @default.
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