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• W1985063313 abstract "p300/CBP is a transcriptional adaptor that integrates signals from many sequence-specific activators via direct interactions. Various cellular and viral factors target p300/CBP to modulate transcription and/or cell cycle progression. One such factor, the cellular p300/CBP associated factor (PCAF), possesses intrinsic histone acetyltransferase activity. Here, we demonstrate that p300/CBP is not only a transcriptional adaptor but also a histone acetyltransferase. p300/CBP represents a novel class of acetyltransferases in that it does not have the conserved motif found among various other acetyltransferases. p300/CBP acetylates all four core histones in nucleosomes. These observations suggest that p300/CBP acetylates nucleosomes in concert with PCAF." @default.
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• W1985063313 date "1996-11-01" @default.
• W1985063313 modified "2023-10-14" @default.
• W1985063313 title "The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases" @default.
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• W1985063313 doi "https://doi.org/10.1016/s0092-8674(00)82001-2" @default.
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