Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985071446> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W1985071446 endingPage "S224" @default.
- W1985071446 startingPage "S224" @default.
- W1985071446 abstract "To compare plasma proteomic profiles of patients presenting with PTL and/or PPROM to those presenting with term labor. Plasma was prospectively collected from women at the time of presentation with (1) PTL between 24-34 weeks gestation and subsequent preterm delivery, (2) PPROM between 24-34 weeks and preterm delivery, and (3) term labor between 37-42 weeks. Samples were analyzed by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) using ProteinChip arrays. We compared SELDI-TOF MS profiles for PTL vs. term labor; PPROM vs. term labor; PTL+PPROM vs. term labor; and PTL vs. PPROM. 8 patients presented with PTL, 7 with PPROM, and 18 with term labor. There were no significant differences in maternal age, race, or education level between the three groups. Mean gestational age at delivery was significantly less in PTL (32.8 weeks) and PPROM (31.9 weeks) patients, when compared to term labor patients (39.1 weeks). A total of 1274 SELDI mass spectra peaks were analyzed. The number of peaks significantly different at p<0.05 using the Mann-Whitney U test ranged from 34-64 for the different comparisons (see table). False Discovery Rate (FDR) analysis was then used to control for multiple hypothesis testing. When analyzing 1274 peaks, 62 peaks would be expected at significance of p<0.05. In addition, for all of the above comparisons, none of the seemingly significantly different peaks met the threshold of validity of a local FDR of <5%.Tabled 1 No differences in plasma proteomic profiles were seen between PTL, PPROM, and term labor patients at the time of presentation. Possible explanations include: 1) differences exist in other compartments (e.g. amniotic fluid) that are not seen in plasma; 2) both term labor and PTL/PPROM may involve similar proteomic changes, regardless of gestational age at presentation; and 3) the methods used here detect 200 of the most abundant plasma proteins, but differences may exist in less abundant proteins (e.g. cytokines)." @default.
- W1985071446 created "2016-06-24" @default.
- W1985071446 creator A5021459490 @default.
- W1985071446 creator A5024154788 @default.
- W1985071446 creator A5031331280 @default.
- W1985071446 creator A5055877622 @default.
- W1985071446 creator A5059155864 @default.
- W1985071446 date "2012-01-01" @default.
- W1985071446 modified "2023-10-16" @default.
- W1985071446 title "492: Plasma proteomic profiles in preterm labor (PTL) and preterm premature rupture of membranes (PPROM)" @default.
- W1985071446 doi "https://doi.org/10.1016/j.ajog.2011.10.510" @default.
- W1985071446 hasPublicationYear "2012" @default.
- W1985071446 type Work @default.
- W1985071446 sameAs 1985071446 @default.
- W1985071446 citedByCount "0" @default.
- W1985071446 crossrefType "journal-article" @default.
- W1985071446 hasAuthorship W1985071446A5021459490 @default.
- W1985071446 hasAuthorship W1985071446A5024154788 @default.
- W1985071446 hasAuthorship W1985071446A5031331280 @default.
- W1985071446 hasAuthorship W1985071446A5055877622 @default.
- W1985071446 hasAuthorship W1985071446A5059155864 @default.
- W1985071446 hasConcept C126322002 @default.
- W1985071446 hasConcept C12868164 @default.
- W1985071446 hasConcept C131872663 @default.
- W1985071446 hasConcept C16685009 @default.
- W1985071446 hasConcept C2777102558 @default.
- W1985071446 hasConcept C2778376644 @default.
- W1985071446 hasConcept C2779234561 @default.
- W1985071446 hasConcept C3019152611 @default.
- W1985071446 hasConcept C46973012 @default.
- W1985071446 hasConcept C54355233 @default.
- W1985071446 hasConcept C71924100 @default.
- W1985071446 hasConcept C86803240 @default.
- W1985071446 hasConceptScore W1985071446C126322002 @default.
- W1985071446 hasConceptScore W1985071446C12868164 @default.
- W1985071446 hasConceptScore W1985071446C131872663 @default.
- W1985071446 hasConceptScore W1985071446C16685009 @default.
- W1985071446 hasConceptScore W1985071446C2777102558 @default.
- W1985071446 hasConceptScore W1985071446C2778376644 @default.
- W1985071446 hasConceptScore W1985071446C2779234561 @default.
- W1985071446 hasConceptScore W1985071446C3019152611 @default.
- W1985071446 hasConceptScore W1985071446C46973012 @default.
- W1985071446 hasConceptScore W1985071446C54355233 @default.
- W1985071446 hasConceptScore W1985071446C71924100 @default.
- W1985071446 hasConceptScore W1985071446C86803240 @default.
- W1985071446 hasIssue "1" @default.
- W1985071446 hasLocation W19850714461 @default.
- W1985071446 hasOpenAccess W1985071446 @default.
- W1985071446 hasPrimaryLocation W19850714461 @default.
- W1985071446 hasRelatedWork W2068429021 @default.
- W1985071446 hasRelatedWork W2151812765 @default.
- W1985071446 hasRelatedWork W2154811448 @default.
- W1985071446 hasRelatedWork W2255123919 @default.
- W1985071446 hasRelatedWork W2752916165 @default.
- W1985071446 hasRelatedWork W3020790965 @default.
- W1985071446 hasRelatedWork W3110426954 @default.
- W1985071446 hasRelatedWork W42015405 @default.
- W1985071446 hasRelatedWork W2193317404 @default.
- W1985071446 hasRelatedWork W79798140 @default.
- W1985071446 hasVolume "206" @default.
- W1985071446 isParatext "false" @default.
- W1985071446 isRetracted "false" @default.
- W1985071446 magId "1985071446" @default.
- W1985071446 workType "article" @default.