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• W1985079446 abstract "Traumatic brain injury (TBI) is associated with schizophrenia, but the causal nature of this relationship is not clear. Three models for their association exist: 1) TBI causes a phenocopy of schizophrenia (parallelism); 2) TBI is a marker of schizophrenia vulnerability (spurious association); and 3) TBI interacts with genetic vulnerability to cause schizophrenia (interaction or effect modification). We found that TBI is a causal component of some cases of schizophrenia, specifically those with enhanced genetic vulnerability. This has biological plausibility. Prevention of 50% of these cases could lead to a savings of $313 million annually in the United States. Further research on critical windows for traumatic brain injury in vulnerable individuals could shed light on the developmental pathophysiology of schizophrenia. Keywords: Traumatic brain injury, schizophrenia, prevention, gene-environment interaction, risk" @default.
• W1985079446 created "2016-06-24" @default.
• W1985079446 creator A5050613769 @default.
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• W1985079446 date "2007-02-01" @default.
• W1985079446 modified "2023-10-16" @default.
• W1985079446 title "Traumatic Brain Injury as a Risk Factor for Schizophrenia" @default.
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• W1985079446 doi "https://doi.org/10.2174/157340007779815646" @default.
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