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• W1985087389 endingPage "535" @default.
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• W1985087389 abstract "Several neurotransmitters including noradrenaline (NA), gamma-aminobutyric acid (GABA) and serotonin (5-HT), and also certain peptides, decrease the duration of the Na+-Ca2+ action potential recorded in cell bodies of embryonic chick dorsal root ganglion neurones maintained in cell culture. To determine if these agents decreased action potential duration by affecting Ca2+ channels (inward current) or K+ channels (outward current) membrane currents were recorded in voltage-clamped sensory neurone somata. 1. Depolarization produced a prominent inward Na+ current and a smaller and slower inward Ca2+ current (ICa). The inactivation of ICa was not simply dependent on membrane potential but apparently required prior entry of Ca2+. Two components of outward current, voltage-activated and Ca2+-activated, were evident in most cells. 2. The effect of NA, and also of GABA and 5-HT, was shown to result from a direct effect on ICa because: NA decreased the TTX-resistant tail current recorded at EK and also the inward current recorded in the presence of 125 mM-TEA and TTX (in which Na+ and K+ currents were blocked). 3. The decrease in ICa is most likely due to an effect on the number of available Ca2+ channels and/or the single Ca2+ channel conductance rather than to a shift in either the kinetics of channel activation or the Ca2+ equilibrium potential. 4. No effect of the several transmitters on the voltage-dependent Na+ and K+ currents was observed. 5. Implications of ICa modulation for the phenomenon of presynaptic inhibition are discussed." @default.
• W1985087389 created "2016-06-24" @default.
• W1985087389 creator A5036965007 @default.
• W1985087389 creator A5039163206 @default.
• W1985087389 date "1981-08-01" @default.
• W1985087389 modified "2023-09-27" @default.
• W1985087389 title "Neurotransmitters decrease the calcium conductance activated by depolarization of embryonic chick sensory neurones." @default.
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• W1985087389 doi "https://doi.org/10.1113/jphysiol.1981.sp013841" @default.
• W1985087389 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1246805" @default.
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