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- W1985093089 abstract "Human memory T cell pools proliferate and differentiate at varying rates that are determined by the frequency of lifelong antigenic re-encounter with different specific antigens. An important question concerning immunity is whether certain specific pools of memory T cells are driven to exhaustion in elderly subjects, a pertinent point in view of increasing human life expectancy. An emerging consensus is that cytomegalovirus (CMV), a beta-herpesvirus with a prevalence of 60-90% worldwide, is an agent that induces specific T cells to extreme differentiation. The question that begs to be answered is whether this can explain why CMV seropositivity and the presence of highly differentiated CMV-specific T cells are included in a cluster of immune parameters that have been shown recently to predict the early mortality of elderly humans." @default.
- W1985093089 created "2016-06-24" @default.
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- W1985093089 date "2005-10-01" @default.
- W1985093089 modified "2023-10-01" @default.
- W1985093089 title "Memory T cell homeostasis and senescence during aging" @default.
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- W1985093089 doi "https://doi.org/10.1016/j.coi.2005.07.019" @default.
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