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- W1985093721 abstract "The interaction of glutamatergic and dopamine neurotransmission is thought to have relevance to both the pathophysiology and pharmacotherapy of schizophrenia. For example, subanesthetic doses of the N-methyl-d-aspartate receptor (NMDA-R) antagonist ketamine induce schizophrenia-like behavioral effects in humans and both behavioral and brain metabolic activation in rodents. Blockade of NMDA-R results in dopamine release, and antipsychotic drugs that block dopamine neurotransmission decrease NMDA-R antagonist-induced behavioral activation. The involvement of dopamine receptors in brain metabolic activation induced by ketamine is, however, unknown. The present study used D1A knockout mice to determine the role of dopamine D1A receptors in the effects of subanesthetic doses of ketamine on both behavioral responses and on alterations in regional [14C]2-deoxyglucose (2-DG) uptake. There was less ketamine-induced behavioral activation in D1A knockout mice than in wild-type mice. In wild-type mice, ketamine (30 mg/kg) induced dramatic increases in 2-DG uptake in limbic cortical regions, hippocampal formation, nucleus accumbens, basolateral amygdala, and caudal parts of the substantia nigra pars reticulata. D1A knockout mice exhibited blunted metabolic activation in response to ketamine in a neuroanatomically specific manner. The selective D1 antagonist, SCH23390 (0.3 mg/kg), inhibited both ketamine-induced brain metabolic activation and behavioral responses in the wild-type mice, with a similar neuroanatomical specificity observed in the D1A knockout mice. Thus, the neuroanatomically selective role that D1A receptors play in ketamine-induced behavior and regional brain metabolic activation in mice provides a useful model for further studies of how the D1A receptor function may be altered in schizophrenia." @default.
- W1985093721 created "2016-06-24" @default.
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- W1985093721 creator A5080560960 @default.
- W1985093721 date "2001-03-01" @default.
- W1985093721 modified "2023-09-23" @default.
- W1985093721 title "Blunted brain metabolic response to ketamine in mice lacking D1A dopamine receptors" @default.
- W1985093721 cites W1589353809 @default.
- W1985093721 cites W1591588997 @default.
- W1985093721 cites W1659384861 @default.
- W1985093721 cites W1888905871 @default.
- W1985093721 cites W1914381346 @default.
- W1985093721 cites W1964804335 @default.
- W1985093721 cites W1965270259 @default.
- W1985093721 cites W1967625698 @default.
- W1985093721 cites W1975860867 @default.
- W1985093721 cites W1976970003 @default.
- W1985093721 cites W1979532884 @default.
- W1985093721 cites W1980034526 @default.
- W1985093721 cites W1980905658 @default.
- W1985093721 cites W1984511767 @default.
- W1985093721 cites W1985161962 @default.
- W1985093721 cites W1986099115 @default.
- W1985093721 cites W1986795023 @default.
- W1985093721 cites W1991333985 @default.
- W1985093721 cites W1993971127 @default.
- W1985093721 cites W1995778321 @default.
- W1985093721 cites W2000890192 @default.
- W1985093721 cites W2009195573 @default.
- W1985093721 cites W2013883034 @default.
- W1985093721 cites W2014159141 @default.
- W1985093721 cites W2015246589 @default.
- W1985093721 cites W2016036141 @default.
- W1985093721 cites W2016723993 @default.
- W1985093721 cites W2018737388 @default.
- W1985093721 cites W2023088131 @default.
- W1985093721 cites W2023770577 @default.
- W1985093721 cites W2023905161 @default.
- W1985093721 cites W2026621438 @default.
- W1985093721 cites W2028884770 @default.
- W1985093721 cites W2031334446 @default.
- W1985093721 cites W2032187584 @default.
- W1985093721 cites W2032687148 @default.
- W1985093721 cites W2033022983 @default.
- W1985093721 cites W2035151323 @default.
- W1985093721 cites W2040113239 @default.
- W1985093721 cites W2042824612 @default.
- W1985093721 cites W2049119531 @default.
- W1985093721 cites W2051687567 @default.
- W1985093721 cites W2051947760 @default.
- W1985093721 cites W2054153218 @default.
- W1985093721 cites W2054843129 @default.
- W1985093721 cites W2056467138 @default.
- W1985093721 cites W2057259844 @default.
- W1985093721 cites W2059698180 @default.
- W1985093721 cites W2061506085 @default.
- W1985093721 cites W2061833498 @default.
- W1985093721 cites W2061913151 @default.
- W1985093721 cites W2067175577 @default.
- W1985093721 cites W2068215811 @default.
- W1985093721 cites W2069234476 @default.
- W1985093721 cites W2069309932 @default.
- W1985093721 cites W2069656785 @default.
- W1985093721 cites W2070639484 @default.
- W1985093721 cites W2077194388 @default.
- W1985093721 cites W2077609442 @default.
- W1985093721 cites W2077767624 @default.
- W1985093721 cites W2083390713 @default.
- W1985093721 cites W2084007108 @default.
- W1985093721 cites W2085426620 @default.
- W1985093721 cites W2086131200 @default.
- W1985093721 cites W2086593869 @default.
- W1985093721 cites W2086723004 @default.
- W1985093721 cites W2087188715 @default.
- W1985093721 cites W2093248761 @default.
- W1985093721 cites W2093795230 @default.
- W1985093721 cites W2094554392 @default.
- W1985093721 cites W2099078941 @default.
- W1985093721 cites W2119779293 @default.
- W1985093721 cites W2129721670 @default.
- W1985093721 cites W2133462240 @default.
- W1985093721 cites W2141858894 @default.
- W1985093721 cites W2158137297 @default.
- W1985093721 cites W2169055778 @default.
- W1985093721 cites W2319440068 @default.
- W1985093721 cites W2326588036 @default.
- W1985093721 cites W2329442555 @default.
- W1985093721 cites W4238505877 @default.
- W1985093721 cites W4849013 @default.
- W1985093721 doi "https://doi.org/10.1016/s0006-8993(01)01991-6" @default.
- W1985093721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11251190" @default.
- W1985093721 hasPublicationYear "2001" @default.
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