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- W1985100654 abstract "The effect of co-administration of granulocyte colony-stimulating factor (G-CSF), as an anti-neutropenia agent, on interferon therapy was examined in a mouse model, in anticipation of an enhancement of interferon efficacy, because neutrophils induced by G-CSF are thought to act as antitumor effectors. G-CSF was intraperitoneally co-administered with human interferon α A/D (IFN) on Day 6 to Day 10 after intradermal inoculation of Meth A fibrosarcoma. Although the co-administration of G-CSF could protect against neutropenia and leukopenia induced by IFN, it did not enhance the regression of tumor, and rather reduced the prolongation of survival time and the long-term survival incidence of IFN therapy. The subsequent in vitro study showed that the antiproliferative activity of peripheral blood leukocytes from Meth A-bearing mice given both IFN and G-CSF was much weaker than that of mice given IFN alone. Whether the observed nullifying effect of G-CSF on IFN therapy is also the case with tumors other than Meth A is open to further study." @default.
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- W1985100654 date "1991-03-01" @default.
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- W1985100654 title "Effect of Co-administration of Granulocyte Colony-stimulating Factor on Interferon Therapy" @default.
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- W1985100654 doi "https://doi.org/10.1111/j.1349-7006.1991.tb01852.x" @default.
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