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• W1985118567 abstract "Journal of Thoracic Oncology ® • Volume 10, Number 1, January 2015 Spontaneous regression (SR) refers to the “partial or complete disappearance of a malignant tumor in the absence of all treatment or in the presence of therapy which is considered inadequate to exert a significant influence on neoplastic disease”. SR is a rare event, estimated to occur in one in 60,000 to one in 100,00 cases of cancer. Although there are reports of SR occurring in different malignancies, many cases of SR occur among patients with renal cell carcinoma, non-Hodgkin’s lymphoma, malignant melanoma, chronic lymphoid leukemia, and neuroblastoma. We describe the first case in the literature of SR of metastatic non–small-cell lung cancer (NSCLC) in the setting of immune reconstitution in an HIV positive individual. At diagnosis, the patient was a 44-year-old male smoker with a past medical history significant for HIV/AIDS diagnosed 20 years earlier, neurosyphilis, and toxoplasmosis, who presented with a severe headache, photophobia, nausea, and vomiting. At the time of his initial presentation, his CD4 count was 77 cells/mm and he had not been adherent to his highly active antiretroviral therapy regimen (HAART). Brain imaging revealed a 1.7 × 1.8 cm ring-enhancing lesion in the posterior right parietal lobe with significant edema and midline shift. He was empirically treated for toxoplasmosis without clinical or radiologic improvement. Craniotomy and excision of the brain mass revealed a poorly differentiated non–small-cell carcinoma with immunohistochemical staining positive for low molecular weight cytokeratin and negative for CK7, CK20, and HMB45 consistent with poorly differentiated NSCLC. CT revealed a right upper lobe nodule (17 × 9 mm), a right adrenal mass (47 × 41 mm), and a heterogeneous mass anterior to the pancreatic body (23 × 24 mm). Biopsies of both the adrenal gland and lung" @default.
• W1985118567 created "2016-06-24" @default.
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• W1985118567 date "2015-01-01" @default.
• W1985118567 modified "2023-09-30" @default.
• W1985118567 title "Spontaneous Regression of Non–Small-Cell Lung Cancer in AIDS After Immune Reconstitution" @default.
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• W1985118567 doi "https://doi.org/10.1097/jto.0000000000000236" @default.
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