Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985125861> ?p ?o ?g. }
- W1985125861 endingPage "1190" @default.
- W1985125861 startingPage "1183" @default.
- W1985125861 abstract "The present study used the endpoint of hypothermia to investigate opioid and neuropeptide FF (NPFF) interactions in conscious animals. Both opioid and NPFF systems played important roles in thermoregulation, which suggested a link between opioid receptors and NPFF receptors in the production of hypothermia. Therefore, we designed a study to investigate the relationship between opioid and NPFF in control of thermoregulation in mice. The selective NPFF receptors antagonist RF9 (30nmol) injected into the third ventricle failed to induce significant effect, but it completely antagonized the hypothermia of NPFF (45 nmol) after cerebral administration in mice. In addition, RF9 (30 nmol) co-injected i.c.v. in the third ventricle reduced the hypothermia induced by morphine (5nmol,) or nociceptin/orphanin FQ (N/OFQ) (2 nmol). Neither the classical opioid receptors antagonist naloxone (10 nmol) nor NOP receptor antagonist [Nphe(1)]NC(1-13)NH(2) (7.5 nmol) reduced the hypothermia induced by the central injection of NPFF at dose of 45 nmol. Co-injected with a low dose of NPFF (5 nmol), the hypothermia of morphine (5 nmol) or N/OFQ (2 nmol) was not modified. These results suggest that NPFF receptors activation is required for opioid to produce hypothermia. In contrast, NPFF-induced hypothermia is mainly mediated by its own receptors, independent of opioid receptors in the mouse brain. This interaction, quantitated in the present study, is the first evidence that NPFF receptors mediate opioid-induced hypothermia in conscious animals." @default.
- W1985125861 created "2016-06-24" @default.
- W1985125861 creator A5002742844 @default.
- W1985125861 creator A5008419280 @default.
- W1985125861 creator A5058864879 @default.
- W1985125861 creator A5070812231 @default.
- W1985125861 creator A5072796155 @default.
- W1985125861 creator A5082818660 @default.
- W1985125861 date "2008-07-01" @default.
- W1985125861 modified "2023-09-27" @default.
- W1985125861 title "Neuropeptide FF receptors antagonist, RF9, attenuates opioid-evoked hypothermia in mice" @default.
- W1985125861 cites W1968198656 @default.
- W1985125861 cites W1968823274 @default.
- W1985125861 cites W1971216816 @default.
- W1985125861 cites W1976547245 @default.
- W1985125861 cites W1983017815 @default.
- W1985125861 cites W1983436781 @default.
- W1985125861 cites W1984553637 @default.
- W1985125861 cites W1988402607 @default.
- W1985125861 cites W1994920434 @default.
- W1985125861 cites W1996450515 @default.
- W1985125861 cites W2001435282 @default.
- W1985125861 cites W2007794217 @default.
- W1985125861 cites W2012008651 @default.
- W1985125861 cites W2015644433 @default.
- W1985125861 cites W2016562510 @default.
- W1985125861 cites W2022044685 @default.
- W1985125861 cites W2040964008 @default.
- W1985125861 cites W2041329114 @default.
- W1985125861 cites W2043129540 @default.
- W1985125861 cites W2048606952 @default.
- W1985125861 cites W2049007357 @default.
- W1985125861 cites W2051618626 @default.
- W1985125861 cites W2057426114 @default.
- W1985125861 cites W2058409797 @default.
- W1985125861 cites W2059099629 @default.
- W1985125861 cites W2059678717 @default.
- W1985125861 cites W2066082102 @default.
- W1985125861 cites W2066624199 @default.
- W1985125861 cites W2068904721 @default.
- W1985125861 cites W2070549314 @default.
- W1985125861 cites W2073275752 @default.
- W1985125861 cites W2076250319 @default.
- W1985125861 cites W2085040288 @default.
- W1985125861 cites W2092657315 @default.
- W1985125861 cites W2093269548 @default.
- W1985125861 cites W2105155111 @default.
- W1985125861 cites W2171229309 @default.
- W1985125861 cites W2180468653 @default.
- W1985125861 cites W4230381786 @default.
- W1985125861 cites W4244838117 @default.
- W1985125861 doi "https://doi.org/10.1016/j.peptides.2008.02.016" @default.
- W1985125861 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18406009" @default.
- W1985125861 hasPublicationYear "2008" @default.
- W1985125861 type Work @default.
- W1985125861 sameAs 1985125861 @default.
- W1985125861 citedByCount "24" @default.
- W1985125861 countsByYear W19851258612012 @default.
- W1985125861 countsByYear W19851258612013 @default.
- W1985125861 countsByYear W19851258612015 @default.
- W1985125861 countsByYear W19851258612017 @default.
- W1985125861 countsByYear W19851258612021 @default.
- W1985125861 countsByYear W19851258612022 @default.
- W1985125861 crossrefType "journal-article" @default.
- W1985125861 hasAuthorship W1985125861A5002742844 @default.
- W1985125861 hasAuthorship W1985125861A5008419280 @default.
- W1985125861 hasAuthorship W1985125861A5058864879 @default.
- W1985125861 hasAuthorship W1985125861A5070812231 @default.
- W1985125861 hasAuthorship W1985125861A5072796155 @default.
- W1985125861 hasAuthorship W1985125861A5082818660 @default.
- W1985125861 hasConcept C100564792 @default.
- W1985125861 hasConcept C118303440 @default.
- W1985125861 hasConcept C125439840 @default.
- W1985125861 hasConcept C126322002 @default.
- W1985125861 hasConcept C134018914 @default.
- W1985125861 hasConcept C170493617 @default.
- W1985125861 hasConcept C185592680 @default.
- W1985125861 hasConcept C2775962371 @default.
- W1985125861 hasConcept C2776885963 @default.
- W1985125861 hasConcept C2777389121 @default.
- W1985125861 hasConcept C2777390192 @default.
- W1985125861 hasConcept C2778122271 @default.
- W1985125861 hasConcept C2778750930 @default.
- W1985125861 hasConcept C2779886867 @default.
- W1985125861 hasConcept C2781063702 @default.
- W1985125861 hasConcept C71924100 @default.
- W1985125861 hasConcept C88016717 @default.
- W1985125861 hasConcept C98274493 @default.
- W1985125861 hasConceptScore W1985125861C100564792 @default.
- W1985125861 hasConceptScore W1985125861C118303440 @default.
- W1985125861 hasConceptScore W1985125861C125439840 @default.
- W1985125861 hasConceptScore W1985125861C126322002 @default.
- W1985125861 hasConceptScore W1985125861C134018914 @default.
- W1985125861 hasConceptScore W1985125861C170493617 @default.
- W1985125861 hasConceptScore W1985125861C185592680 @default.
- W1985125861 hasConceptScore W1985125861C2775962371 @default.
- W1985125861 hasConceptScore W1985125861C2776885963 @default.
- W1985125861 hasConceptScore W1985125861C2777389121 @default.