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- W1985126041 abstract "A continuous flow tubing reactor can be used to readily transform methyl or ethyl carboxylic esters into the corresponding hydroxamic acids. Flow rate, reactor volume, and temperature were optimized for the preparation of a small collection of hydroxamic acids. Synthetic advantages were identified as an increased reaction rate and higher product purity. This method was also successfully applied to the multistep preparation of suberoylanilide hydroxamic acid, a potent HDAC inhibitor used in anticancer therapy." @default.
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- W1985126041 date "2009-04-07" @default.
- W1985126041 modified "2023-10-18" @default.
- W1985126041 title "Efficient Continuous Flow Synthesis of Hydroxamic Acids and Suberoylanilide Hydroxamic Acid Preparation" @default.
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- W1985126041 doi "https://doi.org/10.1021/jo900144h" @default.
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