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• W1985131511 abstract "A serial examination of three groups of cattle infected intravenously (iv) (Group 1, n=8) or subcutaneously (sc) (Group 2, n=8) with live Neospora caninum tachyzoites or with VERO cells (Group 3, n=8) at 70 days’ gestation was carried out and the nature of the inflammatory responses in the placenta and the presence of parasite antigen were analysed. Immune cells expressing CD3, CD4, CD8, gamma delta (γδ) T-cell receptors (TCR), CD79α cytoplasmic (cy) (B cells) and NKp46 [natural killer (NK) cells] antigens were identified immunohistochemically and cells expressing mRNA for interferon-γ (IFN-γ) were labelled by in-situ hybridization. Intravenous inoculation caused mortality in all fetuses from 28 days post-inoculation (dpi) onwards. Subcutaneous inoculation caused mortality in 50% of the animals by 28 dpi. Pathological changes in the placenta consisted of necrosis of fetal placental villi, necrosis and inflammation in adjacent areas of the maternal septum and inflammation at the base of the maternal caruncle. The inflammatory infiltrate consisted mainly of CD3+ lymphocytes, dominated by CD4+ and γδ TCR+ cells, with CD8+ cells present to a lesser extent. The results from the control group indicated fewer NK cells than those occurring in the placenta of human beings or mice. Infiltration of CD4+ cells and NKp46+ cells was observed in the caruncular base and septa 14 days after infection, whereas infiltration of γδ TCR+ cells was observed from 28 dpi onwards. To our knowledge this is the first report on the presence and distribution of NK cells in the bovine placenta. Maternal inflammatory cells expressing mRNA for IFN-γ were identified in animals inoculated with parasites iv or sc at 14 and 28 dpi, respectively. In the sc-inoculated dams with live fetuses at 28, 42 and 56 dpi, there was no evidence of parasite antigen, infiltration of immune cells or production of IFN-γ, suggesting that the parasite had not reached the placenta. The exact cause of fetal death was not established. Tissue destruction by the parasite may have occurred; in addition, there may have been a T helper 1 (Th-1) immune response to the neospora infection at the materno–fetal interface, resulting in infiltrations of CD4 T cells, γδ T cells and NK cells and the subsequent production of IFN-γ. It is possible that a pro-inflammatory Th-1 response early in gestation protects the dam by eliminating the parasite; however, it may lead to destruction of the placental tissues themselves and thus be incompatible with fetal survival." @default.
• W1985131511 created "2016-06-24" @default.
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• W1985131511 date "2006-08-01" @default.
• W1985131511 modified "2023-09-26" @default.
• W1985131511 title "Characterization of the Immune Response in the Placenta of Cattle Experimentally Infected with Neospora caninum in Early Gestation" @default.
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• W1985131511 doi "https://doi.org/10.1016/j.jcpa.2006.07.001" @default.
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