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• W1985133721 abstract "Cold allodynia is a common complaint in patients with peripheral neuropathies. However, cold sensitivity of the different types of sensory afferents present in injured nerves is poorly known. We recorded activity evoked by cold in intact sensory fibers of the skin-saphenous nerve preparation and in axotomized sensory fibers of ∼21 days-old neuromas of the saphenous nerve of mice, in vitro. Sixteen percent of the axotomized units responded to cooling with an accelerating discharge, which stopped immediately during rewarming. This response was similar to that observed in the intact cold-sensitive fibers. Temperature threshold distribution was broad in intact and axotomized cold fibers (30.7–22 °C and 34.5–14.5 °C, respectively). One-third of the axotomized cold-sensitive fibers were mechanosensitive and none of them displayed spontaneous activity at baseline temperature. In contrast, 33% of intact cold-sensitive fibers exhibited low rates of ongoing discharges. In 60% of the cold-sensitive, axotomized units, cold threshold was shifted towards warmer values by the TRPM8 agonist l-menthol. Seventy percent of axotomized, cold-insensitive units developed sensitivity to cold when exposed to 4-aminopyridine and their mean cold threshold (∼28 °C) was unaffected by menthol. Their response properties differed greatly from those of cold-sensitive units. In conclusion, the transducing capacity to cold stimuli is substantially recovered in neuromas. Furthermore, axotomized fibers maintain the 4-AP-sensitive, voltage-activated, transient potassium conductance that counteracts the depolarizing effects of cold in the majority of intact, cold-insensitive primary afferents. Our results indicate that injured nociceptors do not develop abnormal cold sensitivity, suggesting that other mechanisms underlie the cold-induced allodynia following peripheral nerve injury." @default.
• W1985133721 created "2016-06-24" @default.
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• W1985133721 date "2006-01-01" @default.
• W1985133721 modified "2023-10-14" @default.
• W1985133721 title "Cold sensitivity in axotomized fibers of experimental neuromas in mice" @default.
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• W1985133721 doi "https://doi.org/10.1016/j.pain.2005.10.006" @default.
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