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• W1985138230 abstract "Activation of the cascade of proteolytic caspases has been identified as the final common pathway of apoptosis in diverse biological systems. We have isolated a gene, termed MRIT , that possesses overall sequence homology to FLICE (MACH), a large prodomain caspase that links the aggregated complex of the death domain receptors of the tumor necrosis factor receptor family to downstream caspases. However, unlike FLICE, the C-terminal domain of MRIT lacks the caspase catalytic consensus sequence QAC(R/Q)G. Nonetheless MRIT activates caspase-dependent death. Using yeast two-hybrid assays, we demonstrate that MRIT associates with caspases possessing large and small prodomains (FLICE, and CPP32/YAMA), as well as with the adaptor molecule FADD. In addition, MRIT simultaneously and independently interacts with BclX L and FLICE in mammalian cells. Thus, MRIT is a mammalian protein that interacts simultaneously with both caspases and a Bcl-2 family member." @default.
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• W1985138230 date "1997-10-14" @default.
• W1985138230 modified "2023-10-16" @default.
• W1985138230 title "MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclX _L and initiates cell death" @default.
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• W1985138230 doi "https://doi.org/10.1073/pnas.94.21.11333" @default.
• W1985138230 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/23459" @default.
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