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- W1985139381 abstract "Abstract The fungistatic action of 3:5-dichloro-4'-fluorothiocarbanilide (951) has been studied in vitro and in vivo . Dermatophytes are inhibited in vitro at concentrations of from 1 : 100 000 to 1 : 1 000 000. Candida albicans , C. tropicalis and Cryptococcus neoformans —as well as Aspergillus fumigatus —are almost insensitive. Phialophora pedrosoi is as sensitive as the dermatophytes, while histoplasms are inhibited at concentrations as low as 1 : 1 000 000. In guinea-pigs, 951 reduces the length of experimental infection by Microsporum canis from almost two months to 22–25 days: comparative studies were made with griseofulvine and 2-dimethylamino-6-β-diethylaminoethoxybenzothiazol. In white mice and white rats the toxicity of the compound is very small. 951 also has an anti-inflammatory and anticongestive effect on the skin of guinea-pig and man; treatment of human skin lesions has given some satisfactory results." @default.
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- W1985139381 date "1962-09-01" @default.
- W1985139381 modified "2023-10-18" @default.
- W1985139381 title "Activite fongistatique, pharmacodynamique et therapeutique du 3:5-dichloro-4'-fluorothiocarbanilide" @default.
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- W1985139381 doi "https://doi.org/10.1016/0006-2952(62)90176-4" @default.
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