FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985146105> ?p ?o ?g. }

• W1985146105 endingPage "202" @default.
• W1985146105 startingPage "195" @default.
• W1985146105 abstract "The TGFB1 gene is a strong functional candidate for regulating genetic susceptibility to osteoporosis. We studied five common polymorphisms of TGFB1 in relation to osteoporosis-related phenotypes in a population-based cohort of 2975 British women, but found no significant association with bone mass, bone loss, bone markers, or fracture.The gene encoding TGFB1 is a strong functional candidate for genetic susceptibility to osteoporosis. Several polymorphisms have been identified in TGFB1, and previous work has suggested that allelic variants of TGFB1 may regulate BMD and susceptibility to osteoporotic fracture.We studied the relationship between common polymorphisms of TGFB1 and several osteoporosis-related phenotypes including BMD at the lumbar spine and femoral neck, measured by DXA; bone loss over a 6-year period; biochemical markers of bone turnover (urinary free deoxypyridinoline and free pyridinoline/creatinine ratio and serum N-terminal propeptide of type 1 collagen), and fractures in a population-based study of 2975 women from the United Kingdom. Participants were genotyped for single nucleotide polymorphisms (SNPs) in the TGFB1 promoter (G-800A; rs1800468; C-509T; rs1800469), exon 1 (T29C; rs1982073 and G74C; rs1982073); and exon 5 (C788T; rs1800471) on PCR-generated fragments of genomic DNA. Haplotypes were constructed from genotype data using the PHASE software program, and genotypes and haplotypes were related to the phenotypes of interest using general linear model ANOVA, with correction for confounding factors including age, height, weight, menopausal status, hormone replacement therapy (HRT) use, physical activity score, and dietary calcium intake.The polymorphisms were in strong linkage disequilibrium, and four common haplotypes accounted for >95% of alleles at the locus. There was no association between individual SNPs and BMD, bone loss, or biochemical markers of bone turnover. Haplotype analysis showed a nominally significant association with femoral neck BMD (p = 0.042) and with incident osteoporotic fracture (p = 0.013), but these were not significant after correcting for multiple testing.Common polymorphic variants of the TGFB1 gene did not influence BMD or bone loss in this population." @default.
• W1985146105 created "2016-06-24" @default.
• W1985146105 creator A5010635935 @default.
• W1985146105 creator A5015200917 @default.
• W1985146105 creator A5015865428 @default.
• W1985146105 creator A5016379322 @default.
• W1985146105 creator A5036667571 @default.
• W1985146105 creator A5048212260 @default.
• W1985146105 creator A5054601678 @default.
• W1985146105 creator A5057623715 @default.
• W1985146105 creator A5059335486 @default.
• W1985146105 creator A5075501082 @default.
• W1985146105 creator A5089451021 @default.
• W1985146105 date "2006-10-23" @default.
• W1985146105 modified "2023-10-02" @default.
• W1985146105 title "Large-Scale Population-Based Study Shows No Association Between Common Polymorphisms of the TGFB1 Gene and BMD in Women" @default.
• W1985146105 cites W1547454641 @default.
• W1985146105 cites W1690786713 @default.
• W1985146105 cites W1768185655 @default.
• W1985146105 cites W1974301108 @default.
• W1985146105 cites W1996503039 @default.
• W1985146105 cites W1998379420 @default.
• W1985146105 cites W2018554518 @default.
• W1985146105 cites W2025067190 @default.
• W1985146105 cites W2026327440 @default.
• W1985146105 cites W2035738652 @default.
• W1985146105 cites W2038143120 @default.
• W1985146105 cites W2041288346 @default.
• W1985146105 cites W2048758730 @default.
• W1985146105 cites W2052652601 @default.
• W1985146105 cites W2057932737 @default.
• W1985146105 cites W2062322802 @default.
• W1985146105 cites W2069270826 @default.
• W1985146105 cites W2077931651 @default.
• W1985146105 cites W2086940637 @default.
• W1985146105 cites W2094934696 @default.
• W1985146105 cites W2103812590 @default.
• W1985146105 cites W2105348001 @default.
• W1985146105 cites W2110755408 @default.
• W1985146105 cites W2125791407 @default.
• W1985146105 cites W2126706674 @default.
• W1985146105 cites W2127835798 @default.
• W1985146105 cites W4206018204 @default.
• W1985146105 doi "https://doi.org/10.1359/jbmr.061016" @default.
• W1985146105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17059371" @default.
• W1985146105 hasPublicationYear "2006" @default.
• W1985146105 type Work @default.
• W1985146105 sameAs 1985146105 @default.
• W1985146105 citedByCount "19" @default.
• W1985146105 countsByYear W19851461052013 @default.
• W1985146105 countsByYear W19851461052017 @default.
• W1985146105 countsByYear W19851461052018 @default.
• W1985146105 countsByYear W19851461052021 @default.
• W1985146105 crossrefType "journal-article" @default.
• W1985146105 hasAuthorship W1985146105A5010635935 @default.
• W1985146105 hasAuthorship W1985146105A5015200917 @default.
• W1985146105 hasAuthorship W1985146105A5015865428 @default.
• W1985146105 hasAuthorship W1985146105A5016379322 @default.
• W1985146105 hasAuthorship W1985146105A5036667571 @default.
• W1985146105 hasAuthorship W1985146105A5048212260 @default.
• W1985146105 hasAuthorship W1985146105A5054601678 @default.
• W1985146105 hasAuthorship W1985146105A5057623715 @default.
• W1985146105 hasAuthorship W1985146105A5059335486 @default.
• W1985146105 hasAuthorship W1985146105A5075501082 @default.
• W1985146105 hasAuthorship W1985146105A5089451021 @default.
• W1985146105 hasConcept C104317684 @default.
• W1985146105 hasConcept C126322002 @default.
• W1985146105 hasConcept C134018914 @default.
• W1985146105 hasConcept C135763542 @default.
• W1985146105 hasConcept C153209595 @default.
• W1985146105 hasConcept C197754878 @default.
• W1985146105 hasConcept C2776541429 @default.
• W1985146105 hasConcept C2776886416 @default.
• W1985146105 hasConcept C2908647359 @default.
• W1985146105 hasConcept C35605836 @default.
• W1985146105 hasConcept C54355233 @default.
• W1985146105 hasConcept C69991583 @default.
• W1985146105 hasConcept C71924100 @default.
• W1985146105 hasConcept C86803240 @default.
• W1985146105 hasConcept C99454951 @default.
• W1985146105 hasConceptScore W1985146105C104317684 @default.
• W1985146105 hasConceptScore W1985146105C126322002 @default.
• W1985146105 hasConceptScore W1985146105C134018914 @default.
• W1985146105 hasConceptScore W1985146105C135763542 @default.
• W1985146105 hasConceptScore W1985146105C153209595 @default.
• W1985146105 hasConceptScore W1985146105C197754878 @default.
• W1985146105 hasConceptScore W1985146105C2776541429 @default.
• W1985146105 hasConceptScore W1985146105C2776886416 @default.
• W1985146105 hasConceptScore W1985146105C2908647359 @default.
• W1985146105 hasConceptScore W1985146105C35605836 @default.
• W1985146105 hasConceptScore W1985146105C54355233 @default.
• W1985146105 hasConceptScore W1985146105C69991583 @default.
• W1985146105 hasConceptScore W1985146105C71924100 @default.
• W1985146105 hasConceptScore W1985146105C86803240 @default.
• W1985146105 hasConceptScore W1985146105C99454951 @default.
• W1985146105 hasIssue "2" @default.
• W1985146105 hasLocation W19851461051 @default.
• W1985146105 hasLocation W19851461052 @default.

• next